Kemstro

• Muscle Relaxants
• Skeletal Muscle Relaxants
• GABA Agonists
• ATC:M03BX01

• Apo-Baclofen
• Baclon
• Kemstro
• Lioresal
• Lioresal Intrathecal
• Novo-Baclofen
• Nu-Baclofen
• Pms-Baclofen

• No information avaliable

C₁₀H₁₂ClNO₂

http://www.rxlist.com/cgi/generic/baclofen.htm

Kemstro FDA

Neth. pat. Appl. 6,407,755; H. Keberle et al., U.S. pat. 3,471,548 (1965, 1969 both to Ciba)

213.661 g/mol

206-208 ^oC

2090 mg/L

Solid

1.42

Tablet; Intrathecal injection

For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity

Baclofen is a muscle relaxant and antispastic. Baclofen is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Although Baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, Baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.

Rapidly and extensively absorbed

LD₅₀=45 mg/kg (male mice, IV); LD₅₀=78 mg/kg (male rat, IV)

Humans and other mammals