Novo-Baclofen
Novo-Baclofen Brand names, Novo-Baclofen Analogs
Novo-Baclofen Brand Names Mixture
- No information avaliable
Novo-Baclofen Chemical_Formula
C10H12ClNO2
Novo-Baclofen RX_link
http://www.rxlist.com/cgi/generic/baclofen.htm
Novo-Baclofen fda sheet
Novo-Baclofen msds (material safety sheet)
Novo-Baclofen Synthesis Reference
Neth. pat. Appl. 6,407,755; H. Keberle et al., U.S. pat. 3,471,548 (1965, 1969 both to Ciba)
Novo-Baclofen Molecular Weight
213.661 g/mol
Novo-Baclofen Melting Point
206-208 oC
Novo-Baclofen H2O Solubility
2090 mg/L
Novo-Baclofen State
Solid
Novo-Baclofen LogP
1.42
Novo-Baclofen Dosage Forms
Tablet; Intrathecal injection
Novo-Baclofen Indication
For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity
Novo-Baclofen Pharmacology
Baclofen is a muscle relaxant and antispastic. Baclofen is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Although Baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, Baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.
Novo-Baclofen Absorption
Rapidly and extensively absorbed
Novo-Baclofen side effects and Toxicity
LD50=45 mg/kg (male mice, IV); LD50=78 mg/kg (male rat, IV)
Novo-Baclofen Patient Information
Novo-Baclofen Organisms Affected
Humans and other mammals
