Baci-rx
Baci-rx Brand names, Baci-rx Analogs
Baci-rx Brand Names Mixture
- No information avaliable
Baci-rx Chemical_Formula
C66H103N17O16S
Baci-rx RX_link
http://www.rxlist.com/cgi/generic3/bacit.htm
Baci-rx fda sheet
Baci-rx msds (material safety sheet)
Baci-rx Synthesis Reference
No information avaliable
Baci-rx Molecular Weight
1422.69 g/mol
Baci-rx Melting Point
221 - 225 oC
Baci-rx H2O Solubility
Freely soluble
Baci-rx State
Solid
Baci-rx LogP
-1.025
Baci-rx Dosage Forms
Drug premix; Ointment; Powder; Powder for solution
Baci-rx Indication
For the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections.
Baci-rx Pharmacology
Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. As a polypeptide, toxic, and difficult to use chemical, Bacitracin doesn't work well orally, however is very effective topically. Bacitracin exerts pronounced antibacterial action in vitro against a variety of gram-positive and a few gram-negative organisms. However, among systemic diseases, only staphylococcal infections qualify for consideration of bacitracin therapy.
Baci-rx Absorption
Absorption of bacitracin following intramuscular injection is rapid and complete. Absorption from the gastrointestinal tract following oral administration is not appreciable. Absorption following topical application is negligible.
Baci-rx side effects and Toxicity
Oral, mouse: LD50 = >3750 mg/kg.
Baci-rx Patient Information
Baci-rx Organisms Affected
Enteric bacteria and other eubacteria
