PharmacyCodes



Aztreonamum [Latin] en es it fr

Aztreonamum [Latin] Brand names, Aztreonamum [Latin] Analogs

Aztreonamum [Latin] Brand Names Mixture

  • No information avaliable

Aztreonamum [Latin] Chemical_Formula

C13H17N5O8S2

Aztreonamum [Latin] RX_link

http://www.rxlist.com/cgi/generic4/azactaminj.htm

Aztreonamum [Latin] fda sheet

Aztreonamum_[Latin] FDA

Aztreonamum [Latin] msds (material safety sheet)

Aztreonamum_[Latin] MSDS

Aztreonamum [Latin] Synthesis Reference

No information avaliable

Aztreonamum [Latin] Molecular Weight

435.435 g/mol

Aztreonamum [Latin] Melting Point

No information avaliable

Aztreonamum [Latin] H2O Solubility

Insoluble

Aztreonamum [Latin] State

Solid

Aztreonamum [Latin] LogP

No information avaliable

Aztreonamum [Latin] Dosage Forms

Solution (plastic container containing a frozen, iso-osmotic, sterile, sodium-free, nonpyrogenic intravenous solution where each 50 mL of solution contains 1 g, or 2 g aztreonam)

Aztreonamum [Latin] Indication

For the treatment of the following infections caused by susceptible gram-negative microorganisms: urinary tract infections, lower respiratory tract infections, septicemia, skin and skin-structure infections, intra-abdominal infections, and gynecologic infections.

Aztreonamum [Latin] Pharmacology

Aztreonam is a monocyclic beta-lactam antibiotic (a monobactam) originally isolated from Chromobacterium violaceum. Aztreonam exhibits potent and specific activity in vitro against a wide spectrum of gram-negative aerobic pathogens including Pseudomonas aeruginosa. It has no useful activity against gram-positive bacteria or anaerobes, but has very broad spectrum against gram-negative aerobes, including Pseudomonas aeruginosa. This has given it the nickname "the magic bullet for aerobic gram-negative bacteria". Aztreonam, unlike the majority of beta-lactam antibiotics, does not induce beta-lactamase activity and its molecular structure confers a high degree of resistance to hydrolysis by beta-lactamases (such as penicillinases and cephalosporinases) produced by most gram-negative and gram-positive pathogens; it is, therefore, usually active against gram-negative aerobic microorganisms that are resistant to antibiotics hydrolyzed by beta-lactamases. It is active against many strains that are multiply-resistant to other antibiotics, such as certain cephalosporins, penicillin, and aminoglycosides. Aztreonam maintains its antimicrobial activity over a pH range of 6 to 8 in vitro, as well as in the presence of human serum and under anaerobic conditions.

Aztreonamum [Latin] Absorption

Less than 1% absorbed from the gastrointestinal tract following oral administration. Completely absorbed following intramuscular administration.

Aztreonamum [Latin] side effects and Toxicity

No information avaliable

Aztreonamum [Latin] Patient Information

No information avaliable

Aztreonamum [Latin] Organisms Affected

Enteric bacteria and other eubacteria