Azactam en es it fr

Azactam Brand names, Azactam Analogs

Azactam Brand Names Mixture

  • No information avaliable

Azactam Chemical_Formula


Azactam RX_link

Azactam fda sheet

Azactam FDA

Azactam msds (material safety sheet)

Azactam MSDS

Azactam Synthesis Reference

No information avaliable

Azactam Molecular Weight

435.435 g/mol

Azactam Melting Point

No information avaliable

Azactam H2O Solubility


Azactam State


Azactam LogP

No information avaliable

Azactam Dosage Forms

Solution (plastic container containing a frozen, iso-osmotic, sterile, sodium-free, nonpyrogenic intravenous solution where each 50 mL of solution contains 1 g, or 2 g aztreonam)

Azactam Indication

For the treatment of the following infections caused by susceptible gram-negative microorganisms: urinary tract infections, lower respiratory tract infections, septicemia, skin and skin-structure infections, intra-abdominal infections, and gynecologic infections.

Azactam Pharmacology

Aztreonam is a monocyclic beta-lactam antibiotic (a monobactam) originally isolated from Chromobacterium violaceum. Aztreonam exhibits potent and specific activity in vitro against a wide spectrum of gram-negative aerobic pathogens including Pseudomonas aeruginosa. It has no useful activity against gram-positive bacteria or anaerobes, but has very broad spectrum against gram-negative aerobes, including Pseudomonas aeruginosa. This has given it the nickname "the magic bullet for aerobic gram-negative bacteria". Aztreonam, unlike the majority of beta-lactam antibiotics, does not induce beta-lactamase activity and its molecular structure confers a high degree of resistance to hydrolysis by beta-lactamases (such as penicillinases and cephalosporinases) produced by most gram-negative and gram-positive pathogens; it is, therefore, usually active against gram-negative aerobic microorganisms that are resistant to antibiotics hydrolyzed by beta-lactamases. It is active against many strains that are multiply-resistant to other antibiotics, such as certain cephalosporins, penicillin, and aminoglycosides. Aztreonam maintains its antimicrobial activity over a pH range of 6 to 8 in vitro, as well as in the presence of human serum and under anaerobic conditions.

Azactam Absorption

Less than 1% absorbed from the gastrointestinal tract following oral administration. Completely absorbed following intramuscular administration.

Azactam side effects and Toxicity

No information avaliable

Azactam Patient Information

No information avaliable

Azactam Organisms Affected

Enteric bacteria and other eubacteria