Axert
Axert Brand names, Axert Analogs
Axert Brand Names Mixture
- No information avaliable
Axert Chemical_Formula
C17H25N3O2S
Axert RX_link
http://www.rxlist.com/cgi/generic2/almotriptan.htm
Axert fda sheet
Axert msds (material safety sheet)
Axert Synthesis Reference
No information avaliable
Axert Molecular Weight
335.465 g/mol
Axert Melting Point
No information avaliable
Axert H2O Solubility
No information avaliable
Axert State
Solid
Axert LogP
1.87
Axert Dosage Forms
Tablet
Axert Indication
For the treatment of acute migraine headache in adults
Axert Pharmacology
Almotriptan is a selective 5-hydroxytryptamine receptor subtype agonist indicated for the acute treatment of migraine attacks with or without aura in adults. Almotriptan is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine. Almotriptan is an agonist for a vascular 5-hydroxytryptamine receptor subtype (probably a member of the 5-HT1D family) having only a weak affinity for 5-HT1A, 5-HT5A, and 5-HT7 receptors and no significant affinity or pharmacological activity at 5-HT2, 5-HT3 or 5-HT4 receptor subtypes or at alpha1-, alpha2-, or beta-adrenergic, dopamine1,; dopamine2; muscarinic, or benzodiazepine receptors. This action in humans correlates with the relief of migraine headache. In addition to causing vasoconstriction, experimental data from animal studies show that Almotriptan also activates 5-HT1 receptors on peripheral terminals of the trigeminal nerve innervating cranial blood vessels, which may also contribute to the antimigrainous effect of Almotriptan in humans.
Axert Absorption
No information avaliable
Axert side effects and Toxicity
No information avaliable
Axert Patient Information
No information avaliable
Axert Organisms Affected
Humans and other mammals
