Axert

• Anti-migraine Agents
• Anti-inflammatory Agents
• Vasoconstrictor Agents
• Selective Serotonin Agonists
• ATC:N02CC05

• Axert
• Eletriptan

• No information avaliable

C₁₇H₂₅N₃O₂S

http://www.rxlist.com/cgi/generic2/almotriptan.htm

Axert FDA

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335.465 g/mol

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Solid

1.87

Tablet

For the treatment of acute migraine headache in adults

Almotriptan is a selective 5-hydroxytryptamine receptor subtype agonist indicated for the acute treatment of migraine attacks with or without aura in adults. Almotriptan is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine. Almotriptan is an agonist for a vascular 5-hydroxytryptamine receptor subtype (probably a member of the 5-HT_1D family) having only a weak affinity for 5-HT_1A, 5-HT_5A, and 5-HT₇ receptors and no significant affinity or pharmacological activity at 5-HT₂, 5-HT₃ or 5-HT₄ receptor subtypes or at alpha1-, alpha2-, or beta-adrenergic, dopamine1,; dopamine2; muscarinic, or benzodiazepine receptors. This action in humans correlates with the relief of migraine headache. In addition to causing vasoconstriction, experimental data from animal studies show that Almotriptan also activates 5-HT₁ receptors on peripheral terminals of the trigeminal nerve innervating cranial blood vessels, which may also contribute to the antimigrainous effect of Almotriptan in humans.

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Humans and other mammals