Atazanavir
Atazanavir Brand names, Atazanavir Analogs
Atazanavir Brand Names Mixture
- No information avaliable
Atazanavir Chemical_Formula
C38H52N6O7
Atazanavir RX_link
http://www.rxlist.com/cgi/generic3/reyataz.htm
Atazanavir fda sheet
Atazanavir msds (material safety sheet)
Atazanavir Synthesis Reference
No information avaliable
Atazanavir Molecular Weight
704.856 g/mol
Atazanavir Melting Point
No information avaliable
Atazanavir H2O Solubility
Free base slightly soluble (4-5 mg/mL)
Atazanavir State
Solid
Atazanavir LogP
4.25
Atazanavir Dosage Forms
Capsule (100 mg, 150 mg, or 200 mg)
Atazanavir Indication
For use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection.
Atazanavir Pharmacology
Atazanavir (ATV) is an azapeptide HIV-1 protease inhibitor (PI). It is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Atazanavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
Atazanavir Absorption
Atazanavir is rapidly absorbed with a Tmax of approximately 2.5 hours. Administration of atazanavir with food enhances bioavailability and reduces pharmacokinetic variability
Atazanavir side effects and Toxicity
No information avaliable
Atazanavir Patient Information
Atazanavir Organisms Affected
Human immunodeficiency virus
