Latazanavir
Latazanavir Brand names, Latazanavir Analogs
Latazanavir Brand Names Mixture
- No information avaliable
Latazanavir Chemical_Formula
C38H52N6O7
Latazanavir RX_link
http://www.rxlist.com/cgi/generic3/reyataz.htm
Latazanavir fda sheet
Latazanavir msds (material safety sheet)
Latazanavir Synthesis Reference
No information avaliable
Latazanavir Molecular Weight
704.856 g/mol
Latazanavir Melting Point
No information avaliable
Latazanavir H2O Solubility
Free base slightly soluble (4-5 mg/mL)
Latazanavir State
Solid
Latazanavir LogP
4.25
Latazanavir Dosage Forms
Capsule (100 mg, 150 mg, or 200 mg)
Latazanavir Indication
For use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection.
Latazanavir Pharmacology
Atazanavir (ATV) is an azapeptide HIV-1 protease inhibitor (PI). It is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Atazanavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
Latazanavir Absorption
Atazanavir is rapidly absorbed with a Tmax of approximately 2.5 hours. Administration of atazanavir with food enhances bioavailability and reduces pharmacokinetic variability
Latazanavir side effects and Toxicity
No information avaliable
Latazanavir Patient Information
Latazanavir Organisms Affected
Human immunodeficiency virus
