ATZ
ATZ Brand names, ATZ Analogs
ATZ Brand Names Mixture
- No information avaliable
ATZ Chemical_Formula
C38H52N6O7
ATZ RX_link
http://www.rxlist.com/cgi/generic3/reyataz.htm
ATZ fda sheet
ATZ msds (material safety sheet)
ATZ Synthesis Reference
No information avaliable
ATZ Molecular Weight
704.856 g/mol
ATZ Melting Point
No information avaliable
ATZ H2O Solubility
Free base slightly soluble (4-5 mg/mL)
ATZ State
Solid
ATZ LogP
4.25
ATZ Dosage Forms
Capsule (100 mg, 150 mg, or 200 mg)
ATZ Indication
For use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection.
ATZ Pharmacology
Atazanavir (ATV) is an azapeptide HIV-1 protease inhibitor (PI). It is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Atazanavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
ATZ Absorption
Atazanavir is rapidly absorbed with a Tmax of approximately 2.5 hours. Administration of atazanavir with food enhances bioavailability and reduces pharmacokinetic variability
ATZ side effects and Toxicity
No information avaliable
ATZ Patient Information
ATZ Organisms Affected
Human immunodeficiency virus
