Arestin
Arestin Brand names, Arestin Analogs
Arestin Brand Names Mixture
- No information avaliable
Arestin Chemical_Formula
C23H27N3O7
Arestin RX_link
http://www.rxlist.com/cgi/generic/minocycline.htm
Arestin fda sheet
Arestin msds (material safety sheet)
Arestin Synthesis Reference
Boothe, Petisi, U.S. Pat. 3,148,212 (1964)
Arestin Molecular Weight
457.477 g/mol
Arestin Melting Point
No information avaliable
Arestin H2O Solubility
52 mg/mL
Arestin State
Solid
Arestin LogP
0.092
Arestin Dosage Forms
Capsules; Subgingival (sustained-release); IV injection
Arestin Indication
For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by Streptococcus pneumoniae and for the treatment of asymptomatic carriers of Neisseria meningitidis.
Arestin Pharmacology
Minocycline, the most lipid soluble and most active tetracycline antibiotic, is, like doxycycline, a long-acting tetracycline. Minocycline's effects are related to the inhibition of protein synthesis. Although minocycline's broader spectrum of activity, compared to other members of the group, includes activity against Neisseria meningitidis, its use as a prophylaxis is no longer recomended because of side effects (dizziness and vertigo). Current research is examining the possible neuroprotective effects of minocycline against progression of Huntington's Disease, an inherited neurodegenerative disorder. The neuroprotective action of minocycline may include its inhibitory effect on 5-lipoxygenase, an inflammatory enzyme associated with brain aging.
Arestin Absorption
Rapidly absorbed from the gastrointestinal tract and absorption is not significantly impaired by ingestion of food or milk. Oral bioavailability is 100%.
Arestin side effects and Toxicity
Minocycline has been observed to cause a dark discoloration of the thyroid in experimental animals (rats, minipigs, dogs and monkeys). In the rat, chronic treatment with minocycline has resulted in goiter accompanied by elevated radioactive iodine uptake and evidence of thyroid tumor production. Minocycline has also been found to produce thyroid hyperplasia in rats and dogs. LD50=2380 mg/kg (rat, oral), LD50=3600 mg/kg (mouse, oral)
Arestin Patient Information
Arestin Organisms Affected
Enteric bacteria and other eubacteria
