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Ambenonium Base Brand names, Ambenonium Base Analogs

Ambenonium Base Brand Names Mixture

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Ambenonium Base Chemical_Formula


Ambenonium Base RX_link

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Ambenonium Base fda sheet

Ambenonium Base msds (material safety sheet)

Ambenonium_Base MSDS

Ambenonium Base Synthesis Reference

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Ambenonium Base Molecular Weight

537.564 g/mol

Ambenonium Base Melting Point

196-199 oC

Ambenonium Base H2O Solubility


Ambenonium Base State


Ambenonium Base LogP

No information avaliable

Ambenonium Base Dosage Forms

Tablet (10 mg)

Ambenonium Base Indication

Ambenonium is used to treat muscle weakness due to muscle disease (myasthenia gravis).

Ambenonium Base Pharmacology

Ambenonium, similar to pyridostigmine and neostigmine, is used for the treatment of muscle weakness and fatigue in people with myasthenia gravis. It is postulated to exert its therapeutic effect by enhancing cholinergic function by inhibiting the hydrolysis of acetylcholine by acetylcholinesterase. Increased levels of acetylcholine has peripheral effects, as acetylcholine is also used in the brain, where it tends to cause excitatory actions. The glands that receive impulses from the parasympathetic part of the autonomic nervous system are also stimulated in the same way. This is why an increase in acetylcholine causes a decreased heart rate and increased production of saliva. Ambenonium is used less commonly than neostigmine or pyridostigmine but may be preferred in patients hypersensitive to the bromide ion. Ambenonium produces fewer muscarinic side effects than neostigmine, but more than pyridostigmine.

Ambenonium Base Absorption

Oral - poorly absorbed from the gastrointestinal tract.

Ambenonium Base side effects and Toxicity

LD50=150±44 mg/kg (orally in mice). Symptoms of overdose include muscle twitching, weakness and paralysis of voluntary muscles including the tongue, shoulders, neck and arms, blood pressure increase (with or without a slowing of heart rate), a sensation of internal trembling, severe anxiety, and panic. Death may occur rapidly if untreated.

Ambenonium Base Patient Information

Ambenonium Base Organisms Affected

Humans and other mammals