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Ambenonum Brand names, Ambenonum Analogs

Ambenonum Brand Names Mixture

  • No information avaliable

Ambenonum Chemical_Formula


Ambenonum RX_link

No information avaliable

Ambenonum fda sheet

Ambenonum msds (material safety sheet)

Ambenonum MSDS

Ambenonum Synthesis Reference

No information avaliable

Ambenonum Molecular Weight

537.564 g/mol

Ambenonum Melting Point

196-199 oC

Ambenonum H2O Solubility


Ambenonum State


Ambenonum LogP

No information avaliable

Ambenonum Dosage Forms

Tablet (10 mg)

Ambenonum Indication

Ambenonium is used to treat muscle weakness due to muscle disease (myasthenia gravis).

Ambenonum Pharmacology

Ambenonium, similar to pyridostigmine and neostigmine, is used for the treatment of muscle weakness and fatigue in people with myasthenia gravis. It is postulated to exert its therapeutic effect by enhancing cholinergic function by inhibiting the hydrolysis of acetylcholine by acetylcholinesterase. Increased levels of acetylcholine has peripheral effects, as acetylcholine is also used in the brain, where it tends to cause excitatory actions. The glands that receive impulses from the parasympathetic part of the autonomic nervous system are also stimulated in the same way. This is why an increase in acetylcholine causes a decreased heart rate and increased production of saliva. Ambenonium is used less commonly than neostigmine or pyridostigmine but may be preferred in patients hypersensitive to the bromide ion. Ambenonium produces fewer muscarinic side effects than neostigmine, but more than pyridostigmine.

Ambenonum Absorption

Oral - poorly absorbed from the gastrointestinal tract.

Ambenonum side effects and Toxicity

LD50=150±44 mg/kg (orally in mice). Symptoms of overdose include muscle twitching, weakness and paralysis of voluntary muscles including the tongue, shoulders, neck and arms, blood pressure increase (with or without a slowing of heart rate), a sensation of internal trembling, severe anxiety, and panic. Death may occur rapidly if untreated.

Ambenonum Patient Information

Ambenonum Organisms Affected

Humans and other mammals