Ambenonium Kation en es it fr

Ambenonium Kation Brand names, Ambenonium Kation Analogs

Ambenonium Kation Brand Names Mixture

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Ambenonium Kation Chemical_Formula


Ambenonium Kation RX_link

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Ambenonium Kation fda sheet

Ambenonium Kation msds (material safety sheet)

Ambenonium_Kation MSDS

Ambenonium Kation Synthesis Reference

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Ambenonium Kation Molecular Weight

537.564 g/mol

Ambenonium Kation Melting Point

196-199 oC

Ambenonium Kation H2O Solubility


Ambenonium Kation State


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Ambenonium Kation Dosage Forms

Tablet (10 mg)

Ambenonium Kation Indication

Ambenonium is used to treat muscle weakness due to muscle disease (myasthenia gravis).

Ambenonium Kation Pharmacology

Ambenonium, similar to pyridostigmine and neostigmine, is used for the treatment of muscle weakness and fatigue in people with myasthenia gravis. It is postulated to exert its therapeutic effect by enhancing cholinergic function by inhibiting the hydrolysis of acetylcholine by acetylcholinesterase. Increased levels of acetylcholine has peripheral effects, as acetylcholine is also used in the brain, where it tends to cause excitatory actions. The glands that receive impulses from the parasympathetic part of the autonomic nervous system are also stimulated in the same way. This is why an increase in acetylcholine causes a decreased heart rate and increased production of saliva. Ambenonium is used less commonly than neostigmine or pyridostigmine but may be preferred in patients hypersensitive to the bromide ion. Ambenonium produces fewer muscarinic side effects than neostigmine, but more than pyridostigmine.

Ambenonium Kation Absorption

Oral - poorly absorbed from the gastrointestinal tract.

Ambenonium Kation side effects and Toxicity

LD50=150±44 mg/kg (orally in mice). Symptoms of overdose include muscle twitching, weakness and paralysis of voluntary muscles including the tongue, shoulders, neck and arms, blood pressure increase (with or without a slowing of heart rate), a sensation of internal trembling, severe anxiety, and panic. Death may occur rapidly if untreated.

Ambenonium Kation Patient Information

Ambenonium Kation Organisms Affected

Humans and other mammals