Ambenonium
Ambenonium Brand names, Ambenonium Analogs
Ambenonium Brand Names Mixture
- No information avaliable
Ambenonium Chemical_Formula
C28H42Cl2N4O2
Ambenonium RX_link
No information avaliable
Ambenonium fda sheet
Ambenonium msds (material safety sheet)
Ambenonium Synthesis Reference
No information avaliable
Ambenonium Molecular Weight
537.564 g/mol
Ambenonium Melting Point
196-199 oC
Ambenonium H2O Solubility
Soluble
Ambenonium State
Solid
Ambenonium LogP
No information avaliable
Ambenonium Dosage Forms
Tablet (10 mg)
Ambenonium Indication
Ambenonium is used to treat muscle weakness due to muscle disease (myasthenia gravis).
Ambenonium Pharmacology
Ambenonium, similar to pyridostigmine and neostigmine, is used for the treatment of muscle weakness and fatigue in people with myasthenia gravis. It is postulated to exert its therapeutic effect by enhancing cholinergic function by inhibiting the hydrolysis of acetylcholine by acetylcholinesterase. Increased levels of acetylcholine has peripheral effects, as acetylcholine is also used in the brain, where it tends to cause excitatory actions. The glands that receive impulses from the parasympathetic part of the autonomic nervous system are also stimulated in the same way. This is why an increase in acetylcholine causes a decreased heart rate and increased production of saliva. Ambenonium is used less commonly than neostigmine or pyridostigmine but may be preferred in patients hypersensitive to the bromide ion. Ambenonium produces fewer muscarinic side effects than neostigmine, but more than pyridostigmine.
Ambenonium Absorption
Oral - poorly absorbed from the gastrointestinal tract.
Ambenonium side effects and Toxicity
LD50=150±44 mg/kg (orally in mice). Symptoms of overdose include muscle twitching, weakness and paralysis of voluntary muscles including the tongue, shoulders, neck and arms, blood pressure increase (with or without a slowing of heart rate), a sensation of internal trembling, severe anxiety, and panic. Death may occur rapidly if untreated.
Ambenonium Patient Information
Ambenonium Organisms Affected
Humans and other mammals
