1,4-alpha-D- glucan glucanohydrolase
Brand names,
1,4-alpha-D- glucan glucanohydrolase
Analogs
1,4-alpha-D- glucan glucanohydrolase
Brand Names Mixture
1,4-alpha-D- glucan glucanohydrolase
Chemical_Formula
C5850H8902N1606O1739S49
1,4-alpha-D- glucan glucanohydrolase
RX_link
http://www.rxlist.com/cgi/generic2/pancrel.htm
1,4-alpha-D- glucan glucanohydrolase
fda sheet
1,4-alpha-D- glucan glucanohydrolase
msds (material safety sheet)
1,4-alpha-D- glucan glucanohydrolase
Synthesis Reference
No information avaliable
1,4-alpha-D- glucan glucanohydrolase
Molecular Weight
131125.6
1,4-alpha-D- glucan glucanohydrolase
Melting Point
48-50 oC (Vinogradov, A.A. et al., Protein Eng. 14:683-689 (2001)).
1,4-alpha-D- glucan glucanohydrolase
H2O Solubility
No information avaliable
1,4-alpha-D- glucan glucanohydrolase
State
Liquid
1,4-alpha-D- glucan glucanohydrolase
LogP
No information avaliable
1,4-alpha-D- glucan glucanohydrolase
Dosage Forms
Tablet
1,4-alpha-D- glucan glucanohydrolase
Indication
For treatment of cystic fibrosis, chronic pancreatitis, pancreatic duct blockage
1,4-alpha-D- glucan glucanohydrolase
Pharmacology
Used in the treatment of cystic fibrosis or pancreatic dysfunction, pancrelipase helps improve fat digestion in the small intestine. Specifically, the lipase, protease and amylase components break down fat, protein, and starches, respectively, in the small intestine. Lipase hydrolyzes fats into glycerol and fatty acids. Protease converts proteins into proteoses and derived substances, while amylase converts starches into dextrins and sugars. Pancreatic enzymes are used to correct maldigestion, malabsorption and pain associated with pancreatic insufficiency. The major maldigestion/malabsorption problems arise from incomplete fat digestion. Exogenous pancrelipase reduces the amount of nitrogen and fat excreted in the stool.
1,4-alpha-D- glucan glucanohydrolase
Absorption
No information avaliable
1,4-alpha-D- glucan glucanohydrolase
side effects and Toxicity
No information avaliable
1,4-alpha-D- glucan glucanohydrolase
Patient Information
No information avaliable
1,4-alpha-D- glucan glucanohydrolase
Organisms Affected
Humans and other mammals