Ropinirolum_[INN-Latin]

Category

Ropinirolum_[INN-Latin]




Useful info

Ropinirolum_[INN-Latin] Brand names, Ropinirolum_[INN-Latin] Analogs

Ropinirolum_[INN-Latin] Brand Names Mixture

  • No information avaliable

    • Ropinirolum_[INN-Latin] Chemical_Formula

    C16H24N2O

    Ropinirolum_[INN-Latin] RX_link

    http://www.rxlist.com/cgi/generic2/ropinirole.htm

    Ropinirolum_[INN-Latin] fda sheet

    Ropinirolum_[INN-Latin] FDA

    Ropinirolum_[INN-Latin] msds (material safety sheet)

    Ropinirolum_[INN-Latin] MSDS

    Ropinirolum_[INN-Latin] Synthesis Reference

    No information avaliable

    Ropinirolum_[INN-Latin] Molecular Weight

    260.375 g/mol

    Ropinirolum_[INN-Latin] Melting Point

    243-250 oC

    Ropinirolum_[INN-Latin] H2O Solubility

    133 mg/mL

    Ropinirolum_[INN-Latin] State

    Solid

    Ropinirolum_[INN-Latin] LogP

    2.72

    Ropinirolum_[INN-Latin] Dosage Forms

    Tablet (0.25 mg, 0.5 mg, 1 mg, 2 mg, 4 mg or 5 mg)

    Ropinirolum_[INN-Latin] Indication

    For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.

    Ropinirolum_[INN-Latin] Pharmacology

    Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes. The relevance of D3 receptor binding in Parkinson's disease is unknown. The mechanism of ropinirole-induced postural hypotension is presumed to be due to a D2 -mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance.

    Ropinirolum_[INN-Latin] Absorption

    Absolute bioavailability is 55%, indicating a first pass effect. Food does not affect the extent of absorption.

    Ropinirolum_[INN-Latin] Toxicity

    Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.

    Ropinirolum_[INN-Latin] Patient Information

    No information avaliable

    Ropinirolum_[INN-Latin] Organisms Affected

    Humans and other mammals