Ropinirol_[INN-Spanish]

Category

Ropinirol_[INN-Spanish]




Useful info

Ropinirol_[INN-Spanish] Brand names, Ropinirol_[INN-Spanish] Analogs

Ropinirol_[INN-Spanish] Brand Names Mixture

  • No information avaliable

    • Ropinirol_[INN-Spanish] Chemical_Formula

    C16H24N2O

    Ropinirol_[INN-Spanish] RX_link

    http://www.rxlist.com/cgi/generic2/ropinirole.htm

    Ropinirol_[INN-Spanish] fda sheet

    Ropinirol_[INN-Spanish] FDA

    Ropinirol_[INN-Spanish] msds (material safety sheet)

    Ropinirol_[INN-Spanish] MSDS

    Ropinirol_[INN-Spanish] Synthesis Reference

    No information avaliable

    Ropinirol_[INN-Spanish] Molecular Weight

    260.375 g/mol

    Ropinirol_[INN-Spanish] Melting Point

    243-250 oC

    Ropinirol_[INN-Spanish] H2O Solubility

    133 mg/mL

    Ropinirol_[INN-Spanish] State

    Solid

    Ropinirol_[INN-Spanish] LogP

    2.72

    Ropinirol_[INN-Spanish] Dosage Forms

    Tablet (0.25 mg, 0.5 mg, 1 mg, 2 mg, 4 mg or 5 mg)

    Ropinirol_[INN-Spanish] Indication

    For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.

    Ropinirol_[INN-Spanish] Pharmacology

    Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes. The relevance of D3 receptor binding in Parkinson's disease is unknown. The mechanism of ropinirole-induced postural hypotension is presumed to be due to a D2 -mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance.

    Ropinirol_[INN-Spanish] Absorption

    Absolute bioavailability is 55%, indicating a first pass effect. Food does not affect the extent of absorption.

    Ropinirol_[INN-Spanish] Toxicity

    Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.

    Ropinirol_[INN-Spanish] Patient Information

    No information avaliable

    Ropinirol_[INN-Spanish] Organisms Affected

    Humans and other mammals