Ropinirole_HCl
Category
Ropinirole_HCl Brand names, Ropinirole_HCl Analogs
Ropinirole_HCl Brand Names Mixture
No information avaliable
Ropinirole_HCl Chemical_Formula
C16H24N2O
Ropinirole_HCl RX_link
http://www.rxlist.com/cgi/generic2/ropinirole.htm
Ropinirole_HCl fda sheet
Ropinirole_HCl msds (material safety sheet)
Ropinirole_HCl Synthesis Reference
No information avaliable
Ropinirole_HCl Molecular Weight
260.375 g/mol
Ropinirole_HCl Melting Point
243-250 oC
Ropinirole_HCl H2O Solubility
133 mg/mL
Ropinirole_HCl State
Solid
Ropinirole_HCl LogP
2.72
Ropinirole_HCl Dosage Forms
Tablet (0.25 mg, 0.5 mg, 1 mg, 2 mg, 4 mg or 5 mg)
Ropinirole_HCl Indication
For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.
Ropinirole_HCl Pharmacology
Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes. The relevance of D3 receptor binding in Parkinson's disease is unknown. The mechanism of ropinirole-induced postural hypotension is presumed to be due to a D2 -mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance.
Ropinirole_HCl Absorption
Absolute bioavailability is 55%, indicating a first pass effect. Food does not affect the extent of absorption.
Ropinirole_HCl Toxicity
Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.
Ropinirole_HCl Patient Information
No information avaliable
Ropinirole_HCl Organisms Affected
Humans and other mammals
