Ropinirole_hydrochloride

Category

Ropinirole_hydrochloride




Useful info

Ropinirole_hydrochloride Brand names, Ropinirole_hydrochloride Analogs

Ropinirole_hydrochloride Brand Names Mixture

  • No information avaliable

    • Ropinirole_hydrochloride Chemical_Formula

    C16H24N2O

    Ropinirole_hydrochloride RX_link

    http://www.rxlist.com/cgi/generic2/ropinirole.htm

    Ropinirole_hydrochloride fda sheet

    Ropinirole_hydrochloride FDA

    Ropinirole_hydrochloride msds (material safety sheet)

    Ropinirole_hydrochloride MSDS

    Ropinirole_hydrochloride Synthesis Reference

    No information avaliable

    Ropinirole_hydrochloride Molecular Weight

    260.375 g/mol

    Ropinirole_hydrochloride Melting Point

    243-250 oC

    Ropinirole_hydrochloride H2O Solubility

    133 mg/mL

    Ropinirole_hydrochloride State

    Solid

    Ropinirole_hydrochloride LogP

    2.72

    Ropinirole_hydrochloride Dosage Forms

    Tablet (0.25 mg, 0.5 mg, 1 mg, 2 mg, 4 mg or 5 mg)

    Ropinirole_hydrochloride Indication

    For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.

    Ropinirole_hydrochloride Pharmacology

    Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes. The relevance of D3 receptor binding in Parkinson's disease is unknown. The mechanism of ropinirole-induced postural hypotension is presumed to be due to a D2 -mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance.

    Ropinirole_hydrochloride Absorption

    Absolute bioavailability is 55%, indicating a first pass effect. Food does not affect the extent of absorption.

    Ropinirole_hydrochloride Toxicity

    Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.

    Ropinirole_hydrochloride Patient Information

    No information avaliable

    Ropinirole_hydrochloride Organisms Affected

    Humans and other mammals