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Pirimetamina
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Pirimetamina Brand names, Pirimetamina Analogs

Pirimetamina Brand Names Mixture

  • Fansidar Tablets (Pyrimethamine + Sulfadoxine)
  • Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
  • Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)

Pirimetamina Chemical_Formula

C12H13ClN4

Pirimetamina RX_link

http://www.rxlist.com/cgi/generic2/pyrime.htm

Pirimetamina fda sheet

Pirimetamina FDA

Pirimetamina msds (material safety sheet)

Pirimetamina MSDS

Pirimetamina Synthesis Reference

Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)

Pirimetamina Molecular Weight

248.711 g/mol

Pirimetamina Melting Point

233.5 oC

Pirimetamina H2O Solubility

121 mg/L

Pirimetamina State

Solid

Pirimetamina LogP

2.607

Pirimetamina Dosage Forms

Tablet

Pirimetamina Indication

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Pirimetamina Pharmacology

Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.

Pirimetamina Absorption

Well absorbed with peak levels occurring between 2 to 6 hours following administration

Pirimetamina side effects and Toxicity

No information avaliable

Pirimetamina Patient Information

Pirimetamina Organisms Affected

Plasmodium