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Malocide Brand names, Malocide Analogs

Malocide Brand Names Mixture

  • Fansidar Tablets (Pyrimethamine + Sulfadoxine)
  • Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
  • Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)

Malocide Chemical_Formula

C12H13ClN4

Malocide RX_link

http://www.rxlist.com/cgi/generic2/pyrime.htm

Malocide fda sheet

Malocide FDA

Malocide msds (material safety sheet)

Malocide MSDS

Malocide Synthesis Reference

Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)

Malocide Molecular Weight

248.711 g/mol

Malocide Melting Point

233.5 oC

Malocide H2O Solubility

121 mg/L

Malocide State

Solid

Malocide LogP

2.607

Malocide Dosage Forms

Tablet

Malocide Indication

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Malocide Pharmacology

Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.

Malocide Absorption

Well absorbed with peak levels occurring between 2 to 6 hours following administration

Malocide side effects and Toxicity

No information avaliable

Malocide Patient Information

Malocide Organisms Affected

Plasmodium