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Daraclor Brand names, Daraclor Analogs

Daraclor Brand Names Mixture

  • Fansidar Tablets (Pyrimethamine + Sulfadoxine)
  • Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
  • Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)

Daraclor Chemical_Formula

C12H13ClN4

Daraclor RX_link

http://www.rxlist.com/cgi/generic2/pyrime.htm

Daraclor fda sheet

Daraclor FDA

Daraclor msds (material safety sheet)

Daraclor MSDS

Daraclor Synthesis Reference

Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)

Daraclor Molecular Weight

248.711 g/mol

Daraclor Melting Point

233.5 oC

Daraclor H2O Solubility

121 mg/L

Daraclor State

Solid

Daraclor LogP

2.607

Daraclor Dosage Forms

Tablet

Daraclor Indication

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Daraclor Pharmacology

Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.

Daraclor Absorption

Well absorbed with peak levels occurring between 2 to 6 hours following administration

Daraclor side effects and Toxicity

No information avaliable

Daraclor Patient Information

Daraclor Organisms Affected

Plasmodium