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Pirimetamin
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Pirimetamin Brand names, Pirimetamin Analogs

Pirimetamin Brand Names Mixture

  • Fansidar Tablets (Pyrimethamine + Sulfadoxine)
  • Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
  • Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)

Pirimetamin Chemical_Formula

C12H13ClN4

Pirimetamin RX_link

http://www.rxlist.com/cgi/generic2/pyrime.htm

Pirimetamin fda sheet

Pirimetamin FDA

Pirimetamin msds (material safety sheet)

Pirimetamin MSDS

Pirimetamin Synthesis Reference

Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)

Pirimetamin Molecular Weight

248.711 g/mol

Pirimetamin Melting Point

233.5 oC

Pirimetamin H2O Solubility

121 mg/L

Pirimetamin State

Solid

Pirimetamin LogP

2.607

Pirimetamin Dosage Forms

Tablet

Pirimetamin Indication

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Pirimetamin Pharmacology

Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.

Pirimetamin Absorption

Well absorbed with peak levels occurring between 2 to 6 hours following administration

Pirimetamin side effects and Toxicity

No information avaliable

Pirimetamin Patient Information

Pirimetamin Organisms Affected

Plasmodium