Pyremethamine

Pyremethamine Brand names, Pyremethamine Analogs

Pyremethamine Brand Names Mixture

Fansidar Tablets (Pyrimethamine + Sulfadoxine)
Quinnoxine-S (Pyrimethamine + Sulfaquinoxaline)
Sulfaquinoxaline-S Liq (Pyrimethamine + Sulfaquinoxaline)

Pyremethamine Chemical_Formula

C₁₂H₁₃ClN₄

Pyremethamine RX_link

http://www.rxlist.com/cgi/generic2/pyrime.htm

Pyremethamine fda sheet

Pyremethamine FDA

Pyremethamine msds (material safety sheet)

Pyremethamine MSDS

Pyremethamine Synthesis Reference

Russel, Hitchings, J. Am. Chem. Soc. 73, 3763 (1951); Hitchings et al., U.S. pats. 2,576,939; 2,579,259, and 2,602,794 (1951 and 1952 to Burroughs Wellcome); Jacob, U.S. pat 2,680,740 (1954 to Rhone-Poulenc)

Pyremethamine Molecular Weight

248.711 g/mol

Pyremethamine Melting Point

233.5 ^oC

Pyremethamine H₂O Solubility

121 mg/L

Pyremethamine State

Solid

Pyremethamine LogP

2.607

Pyremethamine Dosage Forms

Tablet

Pyremethamine Indication

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Pyremethamine Pharmacology

Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.

Pyremethamine Absorption

Well absorbed with peak levels occurring between 2 to 6 hours following administration

Pyremethamine side effects and Toxicity

No information avaliable

Pyremethamine Patient Information

Pyremethamine Organisms Affected

Plasmodium