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Anco Brand names, Anco Analogs

Anco Brand Names Mixture

  • No information avaliable

Anco Chemical_Formula

C4H4FN3O

Anco RX_link

http://www.rxlist.com/cgi/generic3/flucytosine.htm

Anco fda sheet

Anco FDA

Anco msds (material safety sheet)

Anco MSDS

Anco Synthesis Reference

No information avaliable

Anco Molecular Weight

129.093 g/mol

Anco Melting Point

296 oC

Anco H2O Solubility

10.5 g/L

Anco State

Solid

Anco LogP

-0.062

Anco Dosage Forms

Capsule (250mg and 500mg)

Anco Indication

For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).

Anco Pharmacology

Flucytosine is an antimetabolite that acts as an antifungal agent with in vitro and in vivo activity against Candida and Cryptococcus. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. Antifungal synergism between Ancobon and polyene antibiotics, particularly amphotericin B, has been reported.

Anco Absorption

Rapidly and virtually completely absorbed following oral administration. Bioavailability 78% to 89%.

Anco side effects and Toxicity

Oral, rat: LD50 = >15 gm/kg.

Anco Patient Information

Bone marrow toxicity can cause anemia, leukopenia, pancytopenia, thrombocytopenia and, rarely, agranulocytosis and eosinophilia. Other side effects can be nausea, vomiting, anorexia, bloating, diarrhea, and, rarely, bowel perforation. Reversible elevations in liver enzymes have been reported. Occasionally, rashes may be a side effect. Some side effects that have only been seen very rarely are confusion, hallucinations, headaches, sedation, vertigo and liver enlargement.There has also been a case of severe allergic-type reaction to the drug in at least one person with AIDS. This type of reaction is called anaphylaxis.

Anco Organisms Affected

Yeast and other fungi