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Ancotil Brand names, Ancotil Analogs

Ancotil Brand Names Mixture

  • No information avaliable

Ancotil Chemical_Formula


Ancotil RX_link

Ancotil fda sheet

Ancotil FDA

Ancotil msds (material safety sheet)

Ancotil MSDS

Ancotil Synthesis Reference

No information avaliable

Ancotil Molecular Weight

129.093 g/mol

Ancotil Melting Point

296 oC

Ancotil H2O Solubility

10.5 g/L

Ancotil State


Ancotil LogP


Ancotil Dosage Forms

Capsule (250mg and 500mg)

Ancotil Indication

For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).

Ancotil Pharmacology

Flucytosine is an antimetabolite that acts as an antifungal agent with in vitro and in vivo activity against Candida and Cryptococcus. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. Antifungal synergism between Ancobon and polyene antibiotics, particularly amphotericin B, has been reported.

Ancotil Absorption

Rapidly and virtually completely absorbed following oral administration. Bioavailability 78% to 89%.

Ancotil side effects and Toxicity

Oral, rat: LD50 = >15 gm/kg.

Ancotil Patient Information

Bone marrow toxicity can cause anemia, leukopenia, pancytopenia, thrombocytopenia and, rarely, agranulocytosis and eosinophilia. Other side effects can be nausea, vomiting, anorexia, bloating, diarrhea, and, rarely, bowel perforation. Reversible elevations in liver enzymes have been reported. Occasionally, rashes may be a side effect. Some side effects that have only been seen very rarely are confusion, hallucinations, headaches, sedation, vertigo and liver enlargement.There has also been a case of severe allergic-type reaction to the drug in at least one person with AIDS. This type of reaction is called anaphylaxis.

Ancotil Organisms Affected

Yeast and other fungi