5-Fluorocystosine

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Useful info

5-Fluorocystosine Brand names, 5-Fluorocystosine Analogs

5-Fluorocystosine Brand Names Mixture

  • No information avaliable

    • 5-Fluorocystosine Chemical_Formula

    C4H4FN3O

    5-Fluorocystosine RX_link

    http://www.rxlist.com/cgi/generic3/flucytosine.htm

    5-Fluorocystosine fda sheet

    5-Fluorocystosine FDA

    5-Fluorocystosine msds (material safety sheet)

    5-Fluorocystosine MSDS

    5-Fluorocystosine Synthesis Reference

    No information avaliable

    5-Fluorocystosine Molecular Weight

    129.093 g/mol

    5-Fluorocystosine Melting Point

    296 oC

    5-Fluorocystosine H2O Solubility

    10.5 g/L

    5-Fluorocystosine State

    Solid

    5-Fluorocystosine LogP

    -0.062

    5-Fluorocystosine Dosage Forms

    Capsule (250mg and 500mg)

    5-Fluorocystosine Indication

    For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).

    5-Fluorocystosine Pharmacology

    Flucytosine is an antimetabolite that acts as an antifungal agent with in vitro and in vivo activity against Candida and Cryptococcus. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. Antifungal synergism between Ancobon and polyene antibiotics, particularly amphotericin B, has been reported.

    5-Fluorocystosine Absorption

    Rapidly and virtually completely absorbed following oral administration. Bioavailability 78% to 89%.

    5-Fluorocystosine Toxicity

    Oral, rat: LD50 = >15 gm/kg.

    5-Fluorocystosine Patient Information

    Bone marrow toxicity can cause anemia, leukopenia, pancytopenia, thrombocytopenia and, rarely, agranulocytosis and eosinophilia. Other side effects can be nausea, vomiting, anorexia, bloating, diarrhea, and, rarely, bowel perforation. Reversible elevations in liver enzymes have been reported. Occasionally, rashes may be a side effect. Some side effects that have only been seen very rarely are confusion, hallucinations, headaches, sedation, vertigo and liver enlargement.There has also been a case of severe allergic-type reaction to the drug in at least one person with AIDS. This type of reaction is called anaphylaxis.

    5-Fluorocystosine Organisms Affected

    Yeast and other fungi