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Ancobon (TN) Brand names, Ancobon (TN) Analogs

Ancobon (TN) Brand Names Mixture

  • No information avaliable

Ancobon (TN) Chemical_Formula


Ancobon (TN) RX_link

Ancobon (TN) fda sheet

Ancobon_(TN) FDA

Ancobon (TN) msds (material safety sheet)

Ancobon_(TN) MSDS

Ancobon (TN) Synthesis Reference

No information avaliable

Ancobon (TN) Molecular Weight

129.093 g/mol

Ancobon (TN) Melting Point

296 oC

Ancobon (TN) H2O Solubility

10.5 g/L

Ancobon (TN) State


Ancobon (TN) LogP


Ancobon (TN) Dosage Forms

Capsule (250mg and 500mg)

Ancobon (TN) Indication

For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).

Ancobon (TN) Pharmacology

Flucytosine is an antimetabolite that acts as an antifungal agent with in vitro and in vivo activity against Candida and Cryptococcus. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. Antifungal synergism between Ancobon and polyene antibiotics, particularly amphotericin B, has been reported.

Ancobon (TN) Absorption

Rapidly and virtually completely absorbed following oral administration. Bioavailability 78% to 89%.

Ancobon (TN) side effects and Toxicity

Oral, rat: LD50 = >15 gm/kg.

Ancobon (TN) Patient Information

Bone marrow toxicity can cause anemia, leukopenia, pancytopenia, thrombocytopenia and, rarely, agranulocytosis and eosinophilia. Other side effects can be nausea, vomiting, anorexia, bloating, diarrhea, and, rarely, bowel perforation. Reversible elevations in liver enzymes have been reported. Occasionally, rashes may be a side effect. Some side effects that have only been seen very rarely are confusion, hallucinations, headaches, sedation, vertigo and liver enlargement.There has also been a case of severe allergic-type reaction to the drug in at least one person with AIDS. This type of reaction is called anaphylaxis.

Ancobon (TN) Organisms Affected

Yeast and other fungi