Ancobon

Category






Useful info

Ancobon Brand names, Ancobon Analogs

Ancobon Brand Names Mixture

  • No information avaliable

    • Ancobon Chemical_Formula

    C4H4FN3O

    Ancobon RX_link

    http://www.rxlist.com/cgi/generic3/flucytosine.htm

    Ancobon fda sheet

    Ancobon FDA

    Ancobon msds (material safety sheet)

    Ancobon MSDS

    Ancobon Synthesis Reference

    No information avaliable

    Ancobon Molecular Weight

    129.093 g/mol

    Ancobon Melting Point

    296 oC

    Ancobon H2O Solubility

    10.5 g/L

    Ancobon State

    Solid

    Ancobon LogP

    -0.062

    Ancobon Dosage Forms

    Capsule (250mg and 500mg)

    Ancobon Indication

    For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).

    Ancobon Pharmacology

    Flucytosine is an antimetabolite that acts as an antifungal agent with in vitro and in vivo activity against Candida and Cryptococcus. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. Antifungal synergism between Ancobon and polyene antibiotics, particularly amphotericin B, has been reported.

    Ancobon Absorption

    Rapidly and virtually completely absorbed following oral administration. Bioavailability 78% to 89%.

    Ancobon Toxicity

    Oral, rat: LD50 = >15 gm/kg.

    Ancobon Patient Information

    Bone marrow toxicity can cause anemia, leukopenia, pancytopenia, thrombocytopenia and, rarely, agranulocytosis and eosinophilia. Other side effects can be nausea, vomiting, anorexia, bloating, diarrhea, and, rarely, bowel perforation. Reversible elevations in liver enzymes have been reported. Occasionally, rashes may be a side effect. Some side effects that have only been seen very rarely are confusion, hallucinations, headaches, sedation, vertigo and liver enlargement.There has also been a case of severe allergic-type reaction to the drug in at least one person with AIDS. This type of reaction is called anaphylaxis.

    Ancobon Organisms Affected

    Yeast and other fungi