Tozalip
Categoria
Tozalip Marchi, Tozalip Analoghi
Tozalip Marchi miscela
Tozalip Formula chimica
C33H35FN2O5
Tozalip RX link
http://www.rxlist.com/cgi/generic/atorvastatin.htm
Tozalip FDA foglio
Tozalip DMS (foglio di materiale di sicurezza)
Tozalip Sintesi di riferimento
BD Roth, US Pat. 5273, 995 (1991, 1993)
Tozalip Peso molecolare
558.64 g/mol
Tozalip Temperatura di fusione
159.2-160.7oC
Tozalip H2O Solubilita
Sale sodico solubile in acqua, il 20,4 ug / mL (pH 2,1), 1,23 mg / ml (pH 6,0)
Tozalip Stato
Solid
Tozalip LogP
6.259
Tozalip Forme di dosaggio
Compressa (10 mg, 20 mg o 40 mg)
Tozalip Indicazione
Per la gestione in aggiunta alla dieta per ridurre le elevate totale-C, C-LDL, Apo B, TG e livelli in pazienti con ipercolesterolemia primaria e dislipidemia mista.
Tozalip Farmacologia
Atorvastatina, un selettivo e competitivo della HMG-CoA reduttasi, è usato per abbassare il colesterolo e trigliceridi nei pazienti con ipercolesterolemia e dislipidemia mista e nel trattamento di omozigote ipercolesterolemia familiare. Atorvastatina ha una struttura unica, lunga emivita, e selettività epatica, spiegando la sua maggiore potenza per abbassare il colesterolo LDL rispetto ad altri inibitori della HMG-CoA reduttasi.
Tozalip Assorbimento
Atorvastatina è assorbita rapidamente dopo somministrazione orale. La biodisponibilità assoluta di atorvastatina (farmaco) è circa il 14% e la disponibilità sistemica degli inibitori della HMG-CoA reduttasi attività inibitoria è circa il 30%.
Tozalip Tossicita
Rabdomiolisi, emorragie agli occhi, e problemi al fegato.
Tozalip Informazioni paziente
Lipitor is a HMG-CoA Reductase Inhibitor, also known as a statin. This class
of treatments for high cholesterol is fairly new, and appears to work by
blocking a liver enzyme which generates cholesterol. This medication appears
to be the most effective in this class of drugs at lowering unhealthy LDL
(low-density lipoprotein) cholesterol levels, in some cases up to 51%. It
can be virtually as effective as an angioplasty in treating stable coronary
artery disease. Currently, this drug is approved for use in patients with
high cholesterol (hypercholesterolemia) due to high LDL levels, hereditary
elevated fat levels (dysbetalipoproteinemia), familial high cholesterol,
and to increase HDL (high-density lipoprotein) levels in patients with high
cholesterol and those with both high cholesterol and high triglycerides (mixed
dyslipidemia). Other accepted uses include the treatment of stable coronary
artery diseas, preventing coronary heart disease, preventing clogged stents
(tubes) placed in coronary arteries after surgery, preventing bone loss in
type two diabetics, stabilizing lipid levels that have been altered by treatment
with protease inhibitors. This treatment should be considered a last resort.
The best way to lower cholesterol is through a program of healthy diet and
exercise, and these should be maintained during treatment with Lipitor.
of treatments for high cholesterol is fairly new, and appears to work by
blocking a liver enzyme which generates cholesterol. This medication appears
to be the most effective in this class of drugs at lowering unhealthy LDL
(low-density lipoprotein) cholesterol levels, in some cases up to 51%. It
can be virtually as effective as an angioplasty in treating stable coronary
artery disease. Currently, this drug is approved for use in patients with
high cholesterol (hypercholesterolemia) due to high LDL levels, hereditary
elevated fat levels (dysbetalipoproteinemia), familial high cholesterol,
and to increase HDL (high-density lipoprotein) levels in patients with high
cholesterol and those with both high cholesterol and high triglycerides (mixed
dyslipidemia). Other accepted uses include the treatment of stable coronary
artery diseas, preventing coronary heart disease, preventing clogged stents
(tubes) placed in coronary arteries after surgery, preventing bone loss in
type two diabetics, stabilizing lipid levels that have been altered by treatment
with protease inhibitors. This treatment should be considered a last resort.
The best way to lower cholesterol is through a program of healthy diet and
exercise, and these should be maintained during treatment with Lipitor.
Tozalip Atto interessato organismi
Gli esseri umani e altri mammiferi
