Atorvastatin calcium salt en es it fr

Atorvastatin calcium salt Brand names, Atorvastatin calcium salt Analogs

Atorvastatin calcium salt Brand Names Mixture

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Atorvastatin calcium salt Chemical_Formula


Atorvastatin calcium salt RX_link

Atorvastatin calcium salt fda sheet

Atorvastatin_calcium_salt FDA

Atorvastatin calcium salt msds (material safety sheet)

Atorvastatin_calcium_salt MSDS

Atorvastatin calcium salt Synthesis Reference

B.D. Roth, U.S. pat. 5,273, 995(1991, 1993)

Atorvastatin calcium salt Molecular Weight

558.64 g/mol

Atorvastatin calcium salt Melting Point


Atorvastatin calcium salt H2O Solubility

Sodium salt soluble in water, 20.4 ug/mL (pH 2.1), 1.23 mg/mL (pH 6.0)

Atorvastatin calcium salt State


Atorvastatin calcium salt LogP


Atorvastatin calcium salt Dosage Forms

Tablet (10 mg, 20 mg, or 40 mg)

Atorvastatin calcium salt Indication

For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia.

Atorvastatin calcium salt Pharmacology

Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor, is used to lower cholesterol and triglycerides in patients with hypercholesterolemia and mixed dyslipidemia and in the treatment of homozygous familial hypercholesterolemia. Atorvastatin has a unique structure, long half-life, and hepatic selectivity, explaining its greater LDL-lowering potency compared to other HMG-CoA reductase inhibitors.

Atorvastatin calcium salt Absorption

Atorvastatin is rapidly absorbed after oral administration. The absolute bioavailability of atorvastatin (parent drug) is approximately 14% and the systemic availability of HMG-CoA reductase inhibitory activity is approximately 30%.

Atorvastatin calcium salt side effects and Toxicity

Rhabdomyolysis, eye hemorrhages, and liver problems.

Atorvastatin calcium salt Patient Information

Lipitor is a HMG-CoA Reductase Inhibitor, also known as a statin. This class
of treatments for high cholesterol is fairly new, and appears to work by
blocking a liver enzyme which generates cholesterol. This medication appears
to be the most effective in this class of drugs at lowering unhealthy LDL
(low-density lipoprotein) cholesterol levels, in some cases up to 51%. It
can be virtually as effective as an angioplasty in treating stable coronary
artery disease. Currently, this drug is approved for use in patients with
high cholesterol (hypercholesterolemia) due to high LDL levels, hereditary
elevated fat levels (dysbetalipoproteinemia), familial high cholesterol,
and to increase HDL (high-density lipoprotein) levels in patients with high
cholesterol and those with both high cholesterol and high triglycerides (mixed
dyslipidemia). Other accepted uses include the treatment of stable coronary
artery diseas, preventing coronary heart disease, preventing clogged stents
(tubes) placed in coronary arteries after surgery, preventing bone loss in
type two diabetics, stabilizing lipid levels that have been altered by treatment
with protease inhibitors. This treatment should be considered a last resort.
The best way to lower cholesterol is through a program of healthy diet and
exercise, and these should be maintained during treatment with Lipitor.

Atorvastatin calcium salt Organisms Affected

Humans and other mammals