Tozalip
Categorie
Tozalip Les marques, Tozalip Analogs
Tozalip Les marques melange
Tozalip Formule chimique
C33H35FN2O5
Tozalip RX lien
http://www.rxlist.com/cgi/generic/atorvastatin.htm
Tozalip FDA fiche
Tozalip msds (fiche de securite des materiaux)
Tozalip Synthese de reference
BD Roth, le brevet américain. 5273, 995 (1991, 1993)
Tozalip Poids moleculaire
558.64 g/mol
Tozalip Point de fusion
159.2-160.7oC
Tozalip H2O Solubilite
Sel de sodium soluble dans l'eau, 20,4 ug / ml (pH 2,1), 1,23 mg / ml (pH 6,0)
Tozalip Etat
Solid
Tozalip LogP
6.259
Tozalip Formes pharmaceutiques
Comprimé (10 mg, 20 mg ou 40 mg)
Tozalip Indication
Pour la gestion en tant que complément d'un régime pour réduire élevées au total-C, le C-LDL, l'apo B, et les taux de TG chez les patients atteints d'hypercholestérolémie primaire et de dyslipidémie mixte.
Tozalip Pharmacologie
L'atorvastatine, un sélectif, compétitif de l'HMG-CoA réductase, est utilisée pour abaisser le cholestérol et les triglycérides chez les patients atteints d'hypercholestérolémie et de dyslipidémie mixte et dans le traitement des homozygotes l'hypercholestérolémie familiale. L'atorvastatine a une structure unique, longue demi-vie, et la sélectivité hépatique, expliquant plus de son taux de LDL-abaisser la puissance par rapport aux autres inhibiteurs de la HMG-CoA réductase.
Tozalip Absorption
L'atorvastatine est rapidement absorbée après administration orale. La biodisponibilité absolue de l'atorvastatine (médicament mère) est d'environ 14% et la disponibilité systémique de l'HMG-CoA réductase est une activité inhibitrice 30% environ.
Tozalip Toxicite
Rhabdomyolyse, hémorragies oculaires et des problèmes de foie.
Tozalip Information pour les patients
Lipitor is a HMG-CoA Reductase Inhibitor, also known as a statin. This class
of treatments for high cholesterol is fairly new, and appears to work by
blocking a liver enzyme which generates cholesterol. This medication appears
to be the most effective in this class of drugs at lowering unhealthy LDL
(low-density lipoprotein) cholesterol levels, in some cases up to 51%. It
can be virtually as effective as an angioplasty in treating stable coronary
artery disease. Currently, this drug is approved for use in patients with
high cholesterol (hypercholesterolemia) due to high LDL levels, hereditary
elevated fat levels (dysbetalipoproteinemia), familial high cholesterol,
and to increase HDL (high-density lipoprotein) levels in patients with high
cholesterol and those with both high cholesterol and high triglycerides (mixed
dyslipidemia). Other accepted uses include the treatment of stable coronary
artery diseas, preventing coronary heart disease, preventing clogged stents
(tubes) placed in coronary arteries after surgery, preventing bone loss in
type two diabetics, stabilizing lipid levels that have been altered by treatment
with protease inhibitors. This treatment should be considered a last resort.
The best way to lower cholesterol is through a program of healthy diet and
exercise, and these should be maintained during treatment with Lipitor.
of treatments for high cholesterol is fairly new, and appears to work by
blocking a liver enzyme which generates cholesterol. This medication appears
to be the most effective in this class of drugs at lowering unhealthy LDL
(low-density lipoprotein) cholesterol levels, in some cases up to 51%. It
can be virtually as effective as an angioplasty in treating stable coronary
artery disease. Currently, this drug is approved for use in patients with
high cholesterol (hypercholesterolemia) due to high LDL levels, hereditary
elevated fat levels (dysbetalipoproteinemia), familial high cholesterol,
and to increase HDL (high-density lipoprotein) levels in patients with high
cholesterol and those with both high cholesterol and high triglycerides (mixed
dyslipidemia). Other accepted uses include the treatment of stable coronary
artery diseas, preventing coronary heart disease, preventing clogged stents
(tubes) placed in coronary arteries after surgery, preventing bone loss in
type two diabetics, stabilizing lipid levels that have been altered by treatment
with protease inhibitors. This treatment should be considered a last resort.
The best way to lower cholesterol is through a program of healthy diet and
exercise, and these should be maintained during treatment with Lipitor.
Tozalip Organismes affectes
Les humains et autres mammifères
