Mutagen
Categoria
Mutagen Marchi, Mutagen Analoghi
Mutagen Marchi miscela
Mutagen Formula chimica
C5H11Cl2N
Mutagen RX link
http://www.rxlist.com/cgi/generic3/mustargen.htm
Mutagen FDA foglio
Mutagen DMS (foglio di materiale di sicurezza)
Mutagen Sintesi di riferimento
Hansen, TK, et al;. J.Org.Chem;. 58; 6; 1359-1366 (1993)
Mutagen Peso molecolare
156.053 g/mol
Mutagen Temperatura di fusione
108-111 oC
Mutagen H2O Solubilita
1.2E 004 mg / L
Mutagen Stato
Solid
Mutagen LogP
1.412
Mutagen Forme di dosaggio
Fiale in polvere per iniezione; soluzione della pelle; Unguento
Mutagen Indicazione
Per il trattamento palliativo della malattia di Hodgkin (fasi III e IV), linfosarcoma, leucemia mieloide cronica o linfocitica cronica, policitemia vera, micosi fungoide, e il carcinoma broncogeno. Anche per il trattamento palliativo di carcinoma metastatico con conseguente versamento.
Mutagen Farmacologia
Mecloretamina noto anche come mustine, mostarda azotata e HN2, è il prototipo di farmaco chemioterapico antitumorale. Successo l'uso clinico di mecloretamina ha dato vita al campo della chemioterapia antitumorale. Il farmaco è un analogo del gas mostarda ed è stata derivata dalla ricerca tossici guerra del gas. Appartiene al gruppo di agenti alchilanti mostarda azotata. Agenti alchilanti lavoro di tre diversi meccanismi tutti che ottenere lo stesso risultato finale - interruzione del funzionamento del DNA e morte cellulare.
Mutagen Assorbimento
Parzialmente assorbito dopo somministrazione intracavitaria, molto probabilmente a causa della disattivazione rapida da fluidi corporei.
Mutagen Tossicita
Sintomi di sovraesposizione includono grave leucopenia, anemia, trombocitopenia, e una diatesi emorragica con conseguente emorragia ritardata possono sviluppare. La morte può seguire. La DL50 per via endovenosa è di 2 mg / kg e 1,6 mg / kg nel topo e nel ratto, rispettivamente.
Mutagen Informazioni paziente
PATIENT INFORMATION
NOTE: This information does not apply if mechlorethamine is applied to skin.
Please see "For the patient: Mechlorethamine for skin".
Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
kinds of cancer. It is a clear liquid that is usually injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of
your chemotherapy may be changed based on your blood counts and/or other side
effects.
Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
helps prevent kidney problems in some kinds of cancer.
Other drugs may interact with mechlorethamine. Tell your doctor if you are
taking any other drugs as your dose may need to be changed. Check with your
doctor or pharmacist before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or
usefulness of mechlorethamine.
Mechlorethamine may cause sterility in men and menopause in women which may
be permanent. If you plan to have children, discuss this with your doctor
before being treated with mechlorethamine.
Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
It is best to use birth control while being treated with mechlorethamine. Tell
your doctor right away if you or your partner becomes pregnant. Do not breast
feed during treatment.
Tell doctors or dentists that you are being treated with mechlorethamine before
you receive any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore
throat; pain or burning when you pass urine; redness, pain or swelling of any
area of your body; sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
red spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Signs of kidney problems such as lower back or side pain, swelling of feet or
lower legs, numbness or tingling in feet or hands.
Signs of gout such as joint pain.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or diarrhea.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
NOTE: This information does not apply if mechlorethamine is applied to skin.
Please see "For the patient: Mechlorethamine for skin".
Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
kinds of cancer. It is a clear liquid that is usually injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of
your chemotherapy may be changed based on your blood counts and/or other
side effects.
Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
helps prevent kidney problems in some kinds of cancer.
Other drugs may interact with mechlorethamine. Tell your doctor if you are
taking any other drugs as your dose may need to be changed. Check with your
doctor or pharmacist before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or
usefulness of mechlorethamine.
Mechlorethamine may cause sterility in men and menopause in women which may
be permanent. If you plan to have children, discuss this with your doctor
before being treated with mechlorethamine.
Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
It is best to use birth control while being treated with mechlorethamine. Tell
your doctor right away if you or your partner becomes pregnant. Do not breast
feed during treatment.
Tell doctors or dentists that you are being treated with mechlorethamine before
you receive any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore
throat; pain or burning when you pass urine; redness, pain or swelling of any
area of your body; sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
red spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Signs of kidney problems such as lower back or side pain, swelling of feet or
lower legs, numbness or tingling in feet or hands.
Signs of gout such as joint pain.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or diarrhea.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
NOTE: This information does not apply if mechlorethamine is applied to skin.
Please see "For the patient: Mechlorethamine for skin".
Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
kinds of cancer. It is a clear liquid that is usually injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of
your chemotherapy may be changed based on your blood counts and/or other side
effects.
Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
helps prevent kidney problems in some kinds of cancer.
Other drugs may interact with mechlorethamine. Tell your doctor if you are
taking any other drugs as your dose may need to be changed. Check with your
doctor or pharmacist before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or
usefulness of mechlorethamine.
Mechlorethamine may cause sterility in men and menopause in women which may
be permanent. If you plan to have children, discuss this with your doctor
before being treated with mechlorethamine.
Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
It is best to use birth control while being treated with mechlorethamine. Tell
your doctor right away if you or your partner becomes pregnant. Do not breast
feed during treatment.
Tell doctors or dentists that you are being treated with mechlorethamine before
you receive any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore
throat; pain or burning when you pass urine; redness, pain or swelling of any
area of your body; sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
red spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Signs of kidney problems such as lower back or side pain, swelling of feet or
lower legs, numbness or tingling in feet or hands.
Signs of gout such as joint pain.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or diarrhea.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
NOTE: This information does not apply if mechlorethamine is applied to skin.
Please see "For the patient: Mechlorethamine for skin".
Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
kinds of cancer. It is a clear liquid that is usually injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of
your chemotherapy may be changed based on your blood counts and/or other
side effects.
Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
helps prevent kidney problems in some kinds of cancer.
Other drugs may interact with mechlorethamine. Tell your doctor if you are
taking any other drugs as your dose may need to be changed. Check with your
doctor or pharmacist before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or
usefulness of mechlorethamine.
Mechlorethamine may cause sterility in men and menopause in women which may
be permanent. If you plan to have children, discuss this with your doctor
before being treated with mechlorethamine.
Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
It is best to use birth control while being treated with mechlorethamine. Tell
your doctor right away if you or your partner becomes pregnant. Do not breast
feed during treatment.
Tell doctors or dentists that you are being treated with mechlorethamine before
you receive any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore
throat; pain or burning when you pass urine; redness, pain or swelling of any
area of your body; sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
red spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Signs of kidney problems such as lower back or side pain, swelling of feet or
lower legs, numbness or tingling in feet or hands.
Signs of gout such as joint pain.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or diarrhea.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
Mutagen Atto interessato organismi
Gli esseri umani e altri mammiferi
