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Mustine note Marchi, Mustine note Analoghi

Mustine note Marchi miscela

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  • Mustine note Formula chimica

    C5H11Cl2N

    Mustine note RX link

    http://www.rxlist.com/cgi/generic3/mustargen.htm

    Mustine note FDA foglio

    Mustine_note FDA

    Mustine note DMS (foglio di materiale di sicurezza)

    Mustine_note MSDS

    Mustine note Sintesi di riferimento

    Hansen, TK, et al;. J.Org.Chem;. 58; 6; 1359-1366 (1993)

    Mustine note Peso molecolare

    156.053 g/mol

    Mustine note Temperatura di fusione

    108-111 oC

    Mustine note H2O Solubilita

    1.2E 004 mg / L

    Mustine note Stato

    Solid

    Mustine note LogP

    1.412

    Mustine note Forme di dosaggio

    Fiale in polvere per iniezione; soluzione della pelle; Unguento

    Mustine note Indicazione

    Per il trattamento palliativo della malattia di Hodgkin (fasi III e IV), linfosarcoma, leucemia mieloide cronica o linfocitica cronica, policitemia vera, micosi fungoide, e il carcinoma broncogeno. Anche per il trattamento palliativo di carcinoma metastatico con conseguente versamento.

    Mustine note Farmacologia

    Mecloretamina noto anche come mustine, mostarda azotata e HN2, è il prototipo di farmaco chemioterapico antitumorale. Successo l'uso clinico di mecloretamina ha dato vita al campo della chemioterapia antitumorale. Il farmaco è un analogo del gas mostarda ed è stata derivata dalla ricerca tossici guerra del gas. Appartiene al gruppo di agenti alchilanti mostarda azotata. Agenti alchilanti lavoro di tre diversi meccanismi tutti che ottenere lo stesso risultato finale - interruzione del funzionamento del DNA e morte cellulare.

    Mustine note Assorbimento

    Parzialmente assorbito dopo somministrazione intracavitaria, molto probabilmente a causa della disattivazione rapida da fluidi corporei.

    Mustine note Tossicita

    Sintomi di sovraesposizione includono grave leucopenia, anemia, trombocitopenia, e una diatesi emorragica con conseguente emorragia ritardata possono sviluppare. La morte può seguire. La DL50 per via endovenosa è di 2 mg / kg e 1,6 mg / kg nel topo e nel ratto, rispettivamente.

    Mustine note Informazioni paziente

    PATIENT INFORMATION

    NOTE: This information does not apply if mechlorethamine is applied to skin.
    Please see "For the patient: Mechlorethamine for skin".

    Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
    kinds of cancer. It is a clear liquid that is usually injected into a vein.
    A blood sample will be taken before each treatment. The dose and timing of
    your chemotherapy may be changed based on your blood counts and/or other side
    effects.
    Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
    helps prevent kidney problems in some kinds of cancer.
    Other drugs may interact with mechlorethamine. Tell your doctor if you are
    taking any other drugs as your dose may need to be changed. Check with your
    doctor or pharmacist before you start taking any new drugs.
    The drinking of alcohol (in small amounts) will not affect the safety or
    usefulness of mechlorethamine.
    Mechlorethamine may cause sterility in men and menopause in women which may
    be permanent. If you plan to have children, discuss this with your doctor
    before being treated with mechlorethamine.
    Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
    It is best to use birth control while being treated with mechlorethamine. Tell
    your doctor right away if you or your partner becomes pregnant. Do not breast
    feed during treatment.
    Tell doctors or dentists that you are being treated with mechlorethamine before
    you receive any treatment from them.

    SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:

    Signs of an infection such as fever (over 100F or 38C); chills; cough; sore
    throat; pain or burning when you pass urine; redness, pain or swelling of any
    area of your body; sores forming anywhere on your body.
    Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
    red spots on skin.
    SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:

    Signs of kidney problems such as lower back or side pain, swelling of feet or
    lower legs, numbness or tingling in feet or hands.
    Signs of gout such as joint pain.
    CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:

    Uncontrolled nausea, vomiting or diarrhea.
    Easy bruising or bleeding.
    Redness, swelling, pain or sores where the needle was placed.
    Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
    Skin rash.
    NOTE: This information does not apply if mechlorethamine is applied to skin.
    Please see "For the patient: Mechlorethamine for skin".

    Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
    kinds of cancer. It is a clear liquid that is usually injected into a vein.
    A blood sample will be taken before each treatment. The dose and timing of
    your chemotherapy may be changed based on your blood counts and/or other
    side effects.
    Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
    helps prevent kidney problems in some kinds of cancer.
    Other drugs may interact with mechlorethamine. Tell your doctor if you are
    taking any other drugs as your dose may need to be changed. Check with your
    doctor or pharmacist before you start taking any new drugs.
    The drinking of alcohol (in small amounts) will not affect the safety or
    usefulness of mechlorethamine.
    Mechlorethamine may cause sterility in men and menopause in women which may
    be permanent. If you plan to have children, discuss this with your doctor
    before being treated with mechlorethamine.
    Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
    It is best to use birth control while being treated with mechlorethamine. Tell
    your doctor right away if you or your partner becomes pregnant. Do not breast
    feed during treatment.
    Tell doctors or dentists that you are being treated with mechlorethamine before
    you receive any treatment from them.

    SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:

    Signs of an infection such as fever (over 100F or 38C); chills; cough; sore
    throat; pain or burning when you pass urine; redness, pain or swelling of any
    area of your body; sores forming anywhere on your body.
    Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
    red spots on skin.
    SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:

    Signs of kidney problems such as lower back or side pain, swelling of feet or
    lower legs, numbness or tingling in feet or hands.
    Signs of gout such as joint pain.
    CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:

    Uncontrolled nausea, vomiting or diarrhea.
    Easy bruising or bleeding.
    Redness, swelling, pain or sores where the needle was placed.
    Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
    Skin rash.

    Mustine note Atto interessato organismi

    Gli esseri umani e altri mammiferi