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MSL Marchi, MSL Analoghi

MSL Marchi miscela

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  • MSL Formula chimica

    C9H13N5O4

    MSL RX link

    http://www.rxlist.com/cgi/generic2/vitrasert.htm

    MSL FDA foglio

    MSL FDA

    MSL DMS (foglio di materiale di sicurezza)

    MSL MSDS

    MSL Sintesi di riferimento

    Alhede, Boerge, et al;. J.Org.Chem;. 56, 6; 2139-2143 (1991)

    MSL Peso molecolare

    255.231 g/mol

    MSL Temperatura di fusione

    250 oC

    MSL H2O Solubilita

    4,3 mg / ml

    MSL Stato

    Solid

    MSL LogP

    -1.438

    MSL Forme di dosaggio

    Occular inserire; capsula orale, iniezione

    MSL Indicazione

    Per l'induzione e di mantenimento nel trattamento del citomegalovirus (CMV) retinite nei pazienti immunocompromessi, inclusi i pazienti con sindrome da immunodeficienza acquisita (AIDS). Utilizzato anche nel trattamento di gravi citomegalovirus (CMV) malattia, compresa la polmonite CMV, malattia da CMV gastrointestinali, e diffuse infezioni da CMV nei pazienti immunocompromessi.

    MSL Farmacologia

    Ganciclovir è un analogo nucleosidico sintetico della 2'-deossiguanosina che inibisce la replicazione del virus herpes sia in vitro che in vivo. Virus umani sono sensibili citomegalovirus (CMV), herpes virus di simplex di -1 e -2 (HSV-1, HSV-2), virus Epstein-Barr (EBV) e del virus della varicella zoster (VZV), tuttavia gli studi clinici sono stati limitati alla valutazione di efficacia nei pazienti con infezione da CMV. Ganciclovir è un profarmaco che è strutturalmente simile alla aciclovir. Inibisce la replicazione del virus dal suo encorporation nel DNA virale. Questo encorporation inibisce dATP e conduce ad un difetto del DNA, arrestare o ritardare il meccanismo virale necessario per diffondere il virus ad altre cellule.

    MSL Assorbimento

    Scarsamente assorbito per via sistemica dopo somministrazione orale. La biodisponibilità in condizioni di digiuno è di circa il 5%, e quando somministrato con il cibo, da 6 a 9% (circa il 30% con un pasto grasso).

    MSL Tossicita

    Orale, mouse LD50:> 2g/kg. Per via endovenosa, il cane LD50: 150mg/kg>. Sintomi di sovradosaggio includono pancitopenia irreversibile, peggioramento dei sintomi gastrointestinali e insufficienza renale acuta. Agente di cancro sospetto.

    MSL Informazioni paziente

    All patients should be informed that the major toxicities of ganciclovir are granulocytopenia
    (neutropenia), anemia and thrombocytopenia and that dose modifications may be required, including
    discontinuation. The importance of close monitoring of blood counts while on therapy should be emphasized.
    Patients should be informed that ganciclovir has been associated with elevations in serum creatinine.

    Patients should be instructed to take CYTOVENE capsules with food to maximize bioavailability.

    Patients should be advised that ganciclovir has caused decreased sperm production in animals and may cause
    infertility in humans. Women of childbearing potential should be advised that ganciclovir causes birth
    defects in animals and should not be used during pregnancy. Women of childbearing potential should be
    advised to use effective contraception during treatment with CYTOVENE-IV or CYTOVENE. Similarly, men
    should be advised to practice barrier contraception during and for at least 90 days following treatment
    with CYTOVENE-IV or CYTOVENE.

    Patients should be advised that ganciclovir causes tumors in animals. Although there is no information
    from human studies, ganciclovir should be considered a potential carcinogen.

    All HIV+ Patients: These patients may be receiving zidovudine (Retrovir?*). Patients should be counseled
    that treatment with both ganciclovir and zidovudine simultaneously may not be tolerated by some patients
    and may result in severe granulocytopenia (neutropenia). Patients with AIDS may be receiving didanosine
    (Videx?#). Patients should be counseled that concomitant treatment with both ganciclovir and didanosine
    can cause didanosine serum concentrations to be significantly increased.

    HIV+ Patients With CMV Retinitis: Ganciclovir is not a cure for CMV retinitis, and immunocompromised
    patients may continue to experience progression of retinitis during or following treatment. Patients
    should be advised to have ophthalmologic follow-up examinations at a minimum of every 4 to 6 weeks while
    being treated with CYTOVENE-IV or CYTOVENE. Some patients will require more frequent follow-up.

    Transplant Recipients: Transplant recipients should be counseled regarding the high frequency of impaired
    renal function in transplant recipients who received CYTOVENE-IV solution in controlled clinical trials,
    particularly in patients receiving concomitant administration of nephrotoxic agents such as cyclosporine
    and amphotericin B. Although the specific mechanism of this toxicity, which in most cases was reversible,
    has not been determined, the higher rate of renal impairment in patients receiving CYTOVENE-IV solution
    compared with those who received placebo in the same trials may indicate that CYTOVENE-IV played a
    significant role.

    MSL Atto interessato organismi

    Herpes virus umano