MMC
Categorie
MMC Les marques, MMC Analogs
MMC Les marques melange
MMC Formule chimique
C15H18N4O5
MMC RX lien
http://www.rxlist.com/cgi/generic3/mitomycin.htm
MMC FDA fiche
MMC msds (fiche de securite des materiaux)
MMC Synthese de reference
Uzu et al;. Agric.Biol.Chem;. 28; 394 401 (1964)
MMC Poids moleculaire
334.327 g/mol
MMC Point de fusion
> 360 oC
MMC H2O Solubilite
Soluble (8430 mg / L)
MMC Etat
Solid
MMC LogP
-2.347
MMC Formes pharmaceutiques
Injection (5, 20, 40 mg / flacon)
MMC Indication
Pour le traitement des tumeurs malignes de la lèvre, cavité buccale, du pharynx, des organes digestifs, péritoine, du sein, et la vessie.
MMC Pharmacologie
La mitomycine est l'un des médicaments de chimiothérapie plus âgés, ce qui a été autour et dans l'utilisation des décennies. Il est un antibiotique qui a été montré pour avoir une activité antitumorale. Mitomycine inhibe sélectivement la synthèse de l'acide désoxyribonucléique (ADN). Le contenu guanine et la cytosine est corrélée avec le degré de mitomycine-induite de réticulation. A des concentrations élevées de la drogue, de l'ARN cellulaire et la synthèse des protéines sont également supprimé. Mitomycine a été montré in vitro pour inhiber des cellules B, cellules T, et la prolifération des macrophages et nuire à la présentation des antigènes, ainsi que la sécrétion d'interféron gamma, TNF et IL-2. .
MMC Absorption
Erratiques.
MMC Toxicite
Oral, souris: DL50 = 23 mg / kg; voie orale, rat: DL50 = 30 mg / kg. Les symptômes de surdose comprennent des nausées et des vomissements.
MMC Information pour les patients
mitomycin C, Mutamycin�
Mitomycin (my-toe-MY-sin) is a drug that is used to treat many kinds of cancer. It
is a clear blue or purple liquid that is injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of your
chemotherapy may be changed based on your blood counts and/or other side effccts.
Other drugs may interact with mitomycin. Tell your doctor if you are taking any
other drugs as your dose may need to be changed. Check with your doctor or pharmacist
before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or usefulness of
mitomycin.
Mitomycin may damage sperm and may harm the baby if used during pregnancy. It is best
to use birth control while being treated with mitomycin. Tell your doctor right away
if you or your partner becomes pregnant. Do not breast feed during treatment.
Tell doctors or dentists that you are being treated with mitomycin before you receive
any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore throat;
pain or burning when you pass urine; redness, pain or swelling of any area of your body;
sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint red
spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Severe skin reaction where you have had radiation.
Signs of anemia such as unusual tiredness or weakness.
Signs of lung problems such as dry cough, shortness of breath or problems breathing.
This may occur up to several months after treatment.
Signs of kidney problems such as decreased urine, blood in urine, swelling of feet
or legs. This may occur up to several months after treatment.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or loss of appetite.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
REPORT ADDITIONAL PROBLEMS TO YOUR DOCTOR.
See Chemotherapy and You: a Guide to Self-help During Treatment available free from
the Canadian Cancer Society for more information on managing side effects.
Mitomycin (my-toe-MY-sin) is a drug that is used to treat many kinds of cancer. It
is a clear blue or purple liquid that is injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of your
chemotherapy may be changed based on your blood counts and/or other side effccts.
Other drugs may interact with mitomycin. Tell your doctor if you are taking any
other drugs as your dose may need to be changed. Check with your doctor or pharmacist
before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or usefulness of
mitomycin.
Mitomycin may damage sperm and may harm the baby if used during pregnancy. It is best
to use birth control while being treated with mitomycin. Tell your doctor right away
if you or your partner becomes pregnant. Do not breast feed during treatment.
Tell doctors or dentists that you are being treated with mitomycin before you receive
any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore throat;
pain or burning when you pass urine; redness, pain or swelling of any area of your body;
sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint red
spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Severe skin reaction where you have had radiation.
Signs of anemia such as unusual tiredness or weakness.
Signs of lung problems such as dry cough, shortness of breath or problems breathing.
This may occur up to several months after treatment.
Signs of kidney problems such as decreased urine, blood in urine, swelling of feet
or legs. This may occur up to several months after treatment.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or loss of appetite.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
REPORT ADDITIONAL PROBLEMS TO YOUR DOCTOR.
See Chemotherapy and You: a Guide to Self-help During Treatment available free from
the Canadian Cancer Society for more information on managing side effects.
MMC Organismes affectes
Les humains et autres mammifères
