MMC
Categoria
MMC Nombres de marca, MMC Analogos
MMC Marca los nombres de mezcla
MMC Formula quimica
C15H18N4O5
MMC RX enlace
http://www.rxlist.com/cgi/generic3/mitomycin.htm
MMC FDA hoja
MMC MSDS (hoja de seguridad de materiales)
MMC Sintesis de referencia
Uzu et al;. Agric.Biol.Chem;. 28, 394401 (1964)
MMC Peso molecular
334.327 g/mol
MMC Punto de fusion
> 360 oC
MMC H2O Solubilidad
Solubles (8430 mg / L)
MMC Estado
Solid
MMC LogP
-2.347
MMC Formas de dosificacion
Inyección (5, 20, 40 mg / vial)
MMC Indicacion
Para el tratamiento de la neoplasia maligna de labio, cavidad oral, faringe, los órganos digestivos, el peritoneo, la mama femenina, y la vejiga urinaria.
MMC Farmacologia
La mitomicina es uno de los medicamentos de quimioterapia más, lo que ha existido y en uso por décadas. Es un antibiótico que ha demostrado tener actividad antitumoral. La mitomicina inhibe selectivamente la síntesis de ácido desoxirribonucleico (ADN). El contenido de guanina y citosina se correlaciona con el grado de mitomicina inducida por entrecruzamiento. En altas concentraciones de la droga, el ARN celular y la síntesis de proteínas son también se suprime. Mitomicina ha demostrado in vitro que inhibe las células B, células T y la proliferación de los macrófagos y poner en peligro la presentación de antígenos, así como la secreción de interferón gamma, TNFa e IL-2. .
MMC Absorcion
Errático.
MMC Toxicidad
Oral, ratón: DL50 = 23 mg / kg; Oral, rata: DL50 = 30 mg / kg. Los síntomas de sobredosis incluyen náuseas y vómitos.
MMC Informacion de Pacientes
mitomycin C, Mutamycin�
Mitomycin (my-toe-MY-sin) is a drug that is used to treat many kinds of cancer. It
is a clear blue or purple liquid that is injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of your
chemotherapy may be changed based on your blood counts and/or other side effccts.
Other drugs may interact with mitomycin. Tell your doctor if you are taking any
other drugs as your dose may need to be changed. Check with your doctor or pharmacist
before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or usefulness of
mitomycin.
Mitomycin may damage sperm and may harm the baby if used during pregnancy. It is best
to use birth control while being treated with mitomycin. Tell your doctor right away
if you or your partner becomes pregnant. Do not breast feed during treatment.
Tell doctors or dentists that you are being treated with mitomycin before you receive
any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore throat;
pain or burning when you pass urine; redness, pain or swelling of any area of your body;
sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint red
spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Severe skin reaction where you have had radiation.
Signs of anemia such as unusual tiredness or weakness.
Signs of lung problems such as dry cough, shortness of breath or problems breathing.
This may occur up to several months after treatment.
Signs of kidney problems such as decreased urine, blood in urine, swelling of feet
or legs. This may occur up to several months after treatment.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or loss of appetite.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
REPORT ADDITIONAL PROBLEMS TO YOUR DOCTOR.
See Chemotherapy and You: a Guide to Self-help During Treatment available free from
the Canadian Cancer Society for more information on managing side effects.
Mitomycin (my-toe-MY-sin) is a drug that is used to treat many kinds of cancer. It
is a clear blue or purple liquid that is injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of your
chemotherapy may be changed based on your blood counts and/or other side effccts.
Other drugs may interact with mitomycin. Tell your doctor if you are taking any
other drugs as your dose may need to be changed. Check with your doctor or pharmacist
before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or usefulness of
mitomycin.
Mitomycin may damage sperm and may harm the baby if used during pregnancy. It is best
to use birth control while being treated with mitomycin. Tell your doctor right away
if you or your partner becomes pregnant. Do not breast feed during treatment.
Tell doctors or dentists that you are being treated with mitomycin before you receive
any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore throat;
pain or burning when you pass urine; redness, pain or swelling of any area of your body;
sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint red
spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Severe skin reaction where you have had radiation.
Signs of anemia such as unusual tiredness or weakness.
Signs of lung problems such as dry cough, shortness of breath or problems breathing.
This may occur up to several months after treatment.
Signs of kidney problems such as decreased urine, blood in urine, swelling of feet
or legs. This may occur up to several months after treatment.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or loss of appetite.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
REPORT ADDITIONAL PROBLEMS TO YOUR DOCTOR.
See Chemotherapy and You: a Guide to Self-help During Treatment available free from
the Canadian Cancer Society for more information on managing side effects.
MMC Organismos afectados
Humanos y otros mamíferos
