MMC
MMC Brand names, MMC Analogs
MMC Brand Names Mixture
- No information avaliable
MMC Chemical_Formula
C15H18N4O5
MMC RX_link
http://www.rxlist.com/cgi/generic3/mitomycin.htm
MMC fda sheet
MMC msds (material safety sheet)
MMC Synthesis Reference
Uzu et al.; Agric.Biol.Chem.; 28; 394,401(1964)
MMC Molecular Weight
334.327 g/mol
MMC Melting Point
> 360 oC
MMC H2O Solubility
Soluble (8430 mg/L)
MMC State
Solid
MMC LogP
-2.347
MMC Dosage Forms
Injection (5, 20, 40 mg/vial)
MMC Indication
For treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder.
MMC Pharmacology
Mitomycin is one of the older chemotherapy drugs, which has been around and in use for decades. It is an antibiotic which has been shown to have antitumor activity. Mitomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. Mitomycin has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2.
MMC Absorption
Erratic.
MMC side effects and Toxicity
Oral, mouse: LD50 = 23 mg/kg; Oral, rat: LD50 = 30 mg/kg. Symptoms of overdose include nausea and vomiting.
MMC Patient Information
mitomycin C, Mutamycin�
Mitomycin (my-toe-MY-sin) is a drug that is used to treat many kinds of cancer. It
is a clear blue or purple liquid that is injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of your
chemotherapy may be changed based on your blood counts and/or other side effccts.
Other drugs may interact with mitomycin. Tell your doctor if you are taking any
other drugs as your dose may need to be changed. Check with your doctor or pharmacist
before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or usefulness of
mitomycin.
Mitomycin may damage sperm and may harm the baby if used during pregnancy. It is best
to use birth control while being treated with mitomycin. Tell your doctor right away
if you or your partner becomes pregnant. Do not breast feed during treatment.
Tell doctors or dentists that you are being treated with mitomycin before you receive
any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore throat;
pain or burning when you pass urine; redness, pain or swelling of any area of your body;
sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint red
spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Severe skin reaction where you have had radiation.
Signs of anemia such as unusual tiredness or weakness.
Signs of lung problems such as dry cough, shortness of breath or problems breathing.
This may occur up to several months after treatment.
Signs of kidney problems such as decreased urine, blood in urine, swelling of feet
or legs. This may occur up to several months after treatment.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or loss of appetite.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
REPORT ADDITIONAL PROBLEMS TO YOUR DOCTOR.
See Chemotherapy and You: a Guide to Self-help During Treatment available free from
the Canadian Cancer Society for more information on managing side effects.
Mitomycin (my-toe-MY-sin) is a drug that is used to treat many kinds of cancer. It
is a clear blue or purple liquid that is injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of your
chemotherapy may be changed based on your blood counts and/or other side effccts.
Other drugs may interact with mitomycin. Tell your doctor if you are taking any
other drugs as your dose may need to be changed. Check with your doctor or pharmacist
before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or usefulness of
mitomycin.
Mitomycin may damage sperm and may harm the baby if used during pregnancy. It is best
to use birth control while being treated with mitomycin. Tell your doctor right away
if you or your partner becomes pregnant. Do not breast feed during treatment.
Tell doctors or dentists that you are being treated with mitomycin before you receive
any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore throat;
pain or burning when you pass urine; redness, pain or swelling of any area of your body;
sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint red
spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Severe skin reaction where you have had radiation.
Signs of anemia such as unusual tiredness or weakness.
Signs of lung problems such as dry cough, shortness of breath or problems breathing.
This may occur up to several months after treatment.
Signs of kidney problems such as decreased urine, blood in urine, swelling of feet
or legs. This may occur up to several months after treatment.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or loss of appetite.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
REPORT ADDITIONAL PROBLEMS TO YOUR DOCTOR.
See Chemotherapy and You: a Guide to Self-help During Treatment available free from
the Canadian Cancer Society for more information on managing side effects.
MMC Organisms Affected
Humans and other mammals
