HN2
Categorie
HN2 Les marques, HN2 Analogs
HN2 Les marques melange
HN2 Formule chimique
C5H11Cl2N
HN2 RX lien
http://www.rxlist.com/cgi/generic3/mustargen.htm
HN2 FDA fiche
HN2 msds (fiche de securite des materiaux)
HN2 Synthese de reference
Hansen, les savoirs traditionnels, et al;. J.Org.Chem;. 58; 6; 1359-1366 (1993)
HN2 Poids moleculaire
156.053 g/mol
HN2 Point de fusion
108-111 oC
HN2 H2O Solubilite
1.2E 004 mg / L
HN2 Etat
Solid
HN2 LogP
1.412
HN2 Formes pharmaceutiques
Flacons de poudre pour solution injectable; solution de la peau; Pommade
HN2 Indication
Pour le traitement palliatif de la maladie de Hodgkin (stades III et IV), lymphosarcome, leucémie myéloïde chronique ou chronique lymphocytaire, maladie de Vaquez, la mycose fongoïde, et le carcinome bronchique. Aussi pour le traitement palliatif du carcinome métastatique entraînant un épanchement.
HN2 Pharmacologie
Méchloréthamine également connu comme mustine, moutarde à l'azote, et HN2, est le prototype de médicaments anticancéreux chimiothérapeutiques. Succès utilisation clinique de méchloréthamine a donné naissance au domaine de la chimiothérapie anticancéreuse. Le médicament est un analogue du gaz moutarde et était issu de la recherche de gaz toxiques de guerre. Il appartient au groupe des agents alkylants azote moutarde. Les agents alkylants travail par trois mécanismes différents qui tous atteindre le même résultat final - la perturbation de la fonction de l'ADN et la mort cellulaire.
HN2 Absorption
Partiellement absorbé après administration intracavitaire, probablement dû à une désactivation rapide par des fluides corporels.
HN2 Toxicite
Symptômes d'une surexposition comprennent leucopénie, anémie, thrombocytopénie, et une diathèse hémorragique avec saignement retardé ultérieurs peuvent se développer. La mort peut suivre. La DL50 par voie intraveineuse est de 2 mg / kg et 1,6 mg / kg chez la souris et le rat, respectivement.
HN2 Information pour les patients
PATIENT INFORMATION
NOTE: This information does not apply if mechlorethamine is applied to skin.
Please see "For the patient: Mechlorethamine for skin".
Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
kinds of cancer. It is a clear liquid that is usually injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of
your chemotherapy may be changed based on your blood counts and/or other side
effects.
Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
helps prevent kidney problems in some kinds of cancer.
Other drugs may interact with mechlorethamine. Tell your doctor if you are
taking any other drugs as your dose may need to be changed. Check with your
doctor or pharmacist before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or
usefulness of mechlorethamine.
Mechlorethamine may cause sterility in men and menopause in women which may
be permanent. If you plan to have children, discuss this with your doctor
before being treated with mechlorethamine.
Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
It is best to use birth control while being treated with mechlorethamine. Tell
your doctor right away if you or your partner becomes pregnant. Do not breast
feed during treatment.
Tell doctors or dentists that you are being treated with mechlorethamine before
you receive any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore
throat; pain or burning when you pass urine; redness, pain or swelling of any
area of your body; sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
red spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Signs of kidney problems such as lower back or side pain, swelling of feet or
lower legs, numbness or tingling in feet or hands.
Signs of gout such as joint pain.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or diarrhea.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
NOTE: This information does not apply if mechlorethamine is applied to skin.
Please see "For the patient: Mechlorethamine for skin".
Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
kinds of cancer. It is a clear liquid that is usually injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of
your chemotherapy may be changed based on your blood counts and/or other
side effects.
Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
helps prevent kidney problems in some kinds of cancer.
Other drugs may interact with mechlorethamine. Tell your doctor if you are
taking any other drugs as your dose may need to be changed. Check with your
doctor or pharmacist before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or
usefulness of mechlorethamine.
Mechlorethamine may cause sterility in men and menopause in women which may
be permanent. If you plan to have children, discuss this with your doctor
before being treated with mechlorethamine.
Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
It is best to use birth control while being treated with mechlorethamine. Tell
your doctor right away if you or your partner becomes pregnant. Do not breast
feed during treatment.
Tell doctors or dentists that you are being treated with mechlorethamine before
you receive any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore
throat; pain or burning when you pass urine; redness, pain or swelling of any
area of your body; sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
red spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Signs of kidney problems such as lower back or side pain, swelling of feet or
lower legs, numbness or tingling in feet or hands.
Signs of gout such as joint pain.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or diarrhea.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
NOTE: This information does not apply if mechlorethamine is applied to skin.
Please see "For the patient: Mechlorethamine for skin".
Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
kinds of cancer. It is a clear liquid that is usually injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of
your chemotherapy may be changed based on your blood counts and/or other side
effects.
Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
helps prevent kidney problems in some kinds of cancer.
Other drugs may interact with mechlorethamine. Tell your doctor if you are
taking any other drugs as your dose may need to be changed. Check with your
doctor or pharmacist before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or
usefulness of mechlorethamine.
Mechlorethamine may cause sterility in men and menopause in women which may
be permanent. If you plan to have children, discuss this with your doctor
before being treated with mechlorethamine.
Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
It is best to use birth control while being treated with mechlorethamine. Tell
your doctor right away if you or your partner becomes pregnant. Do not breast
feed during treatment.
Tell doctors or dentists that you are being treated with mechlorethamine before
you receive any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore
throat; pain or burning when you pass urine; redness, pain or swelling of any
area of your body; sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
red spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Signs of kidney problems such as lower back or side pain, swelling of feet or
lower legs, numbness or tingling in feet or hands.
Signs of gout such as joint pain.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or diarrhea.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
NOTE: This information does not apply if mechlorethamine is applied to skin.
Please see "For the patient: Mechlorethamine for skin".
Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
kinds of cancer. It is a clear liquid that is usually injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of
your chemotherapy may be changed based on your blood counts and/or other
side effects.
Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
helps prevent kidney problems in some kinds of cancer.
Other drugs may interact with mechlorethamine. Tell your doctor if you are
taking any other drugs as your dose may need to be changed. Check with your
doctor or pharmacist before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or
usefulness of mechlorethamine.
Mechlorethamine may cause sterility in men and menopause in women which may
be permanent. If you plan to have children, discuss this with your doctor
before being treated with mechlorethamine.
Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
It is best to use birth control while being treated with mechlorethamine. Tell
your doctor right away if you or your partner becomes pregnant. Do not breast
feed during treatment.
Tell doctors or dentists that you are being treated with mechlorethamine before
you receive any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore
throat; pain or burning when you pass urine; redness, pain or swelling of any
area of your body; sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
red spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Signs of kidney problems such as lower back or side pain, swelling of feet or
lower legs, numbness or tingling in feet or hands.
Signs of gout such as joint pain.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or diarrhea.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
HN2 Organismes affectes
Les humains et autres mammifères
