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Chlorethazine Les marques, Chlorethazine Analogs

Chlorethazine Les marques melange

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  • Chlorethazine Formule chimique

    C5H11Cl2N

    Chlorethazine RX lien

    http://www.rxlist.com/cgi/generic3/mustargen.htm

    Chlorethazine FDA fiche

    Chlorethazine FDA

    Chlorethazine msds (fiche de securite des materiaux)

    Chlorethazine MSDS

    Chlorethazine Synthese de reference

    Hansen, les savoirs traditionnels, et al;. J.Org.Chem;. 58; 6; 1359-1366 (1993)

    Chlorethazine Poids moleculaire

    156.053 g/mol

    Chlorethazine Point de fusion

    108-111 oC

    Chlorethazine H2O Solubilite

    1.2E 004 mg / L

    Chlorethazine Etat

    Solid

    Chlorethazine LogP

    1.412

    Chlorethazine Formes pharmaceutiques

    Flacons de poudre pour solution injectable; solution de la peau; Pommade

    Chlorethazine Indication

    Pour le traitement palliatif de la maladie de Hodgkin (stades III et IV), lymphosarcome, leucémie myéloïde chronique ou chronique lymphocytaire, maladie de Vaquez, la mycose fongoïde, et le carcinome bronchique. Aussi pour le traitement palliatif du carcinome métastatique entraînant un épanchement.

    Chlorethazine Pharmacologie

    Méchloréthamine également connu comme mustine, moutarde à l'azote, et HN2, est le prototype de médicaments anticancéreux chimiothérapeutiques. Succès utilisation clinique de méchloréthamine a donné naissance au domaine de la chimiothérapie anticancéreuse. Le médicament est un analogue du gaz moutarde et était issu de la recherche de gaz toxiques de guerre. Il appartient au groupe des agents alkylants azote moutarde. Les agents alkylants travail par trois mécanismes différents qui tous atteindre le même résultat final - la perturbation de la fonction de l'ADN et la mort cellulaire.

    Chlorethazine Absorption

    Partiellement absorbé après administration intracavitaire, probablement dû à une désactivation rapide par des fluides corporels.

    Chlorethazine Toxicite

    Symptômes d'une surexposition comprennent leucopénie, anémie, thrombocytopénie, et une diathèse hémorragique avec saignement retardé ultérieurs peuvent se développer. La mort peut suivre. La DL50 par voie intraveineuse est de 2 mg / kg et 1,6 mg / kg chez la souris et le rat, respectivement.

    Chlorethazine Information pour les patients

    PATIENT INFORMATION

    NOTE: This information does not apply if mechlorethamine is applied to skin.
    Please see "For the patient: Mechlorethamine for skin".

    Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
    kinds of cancer. It is a clear liquid that is usually injected into a vein.
    A blood sample will be taken before each treatment. The dose and timing of
    your chemotherapy may be changed based on your blood counts and/or other side
    effects.
    Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
    helps prevent kidney problems in some kinds of cancer.
    Other drugs may interact with mechlorethamine. Tell your doctor if you are
    taking any other drugs as your dose may need to be changed. Check with your
    doctor or pharmacist before you start taking any new drugs.
    The drinking of alcohol (in small amounts) will not affect the safety or
    usefulness of mechlorethamine.
    Mechlorethamine may cause sterility in men and menopause in women which may
    be permanent. If you plan to have children, discuss this with your doctor
    before being treated with mechlorethamine.
    Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
    It is best to use birth control while being treated with mechlorethamine. Tell
    your doctor right away if you or your partner becomes pregnant. Do not breast
    feed during treatment.
    Tell doctors or dentists that you are being treated with mechlorethamine before
    you receive any treatment from them.

    SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:

    Signs of an infection such as fever (over 100F or 38C); chills; cough; sore
    throat; pain or burning when you pass urine; redness, pain or swelling of any
    area of your body; sores forming anywhere on your body.
    Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
    red spots on skin.
    SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:

    Signs of kidney problems such as lower back or side pain, swelling of feet or
    lower legs, numbness or tingling in feet or hands.
    Signs of gout such as joint pain.
    CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:

    Uncontrolled nausea, vomiting or diarrhea.
    Easy bruising or bleeding.
    Redness, swelling, pain or sores where the needle was placed.
    Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
    Skin rash.
    NOTE: This information does not apply if mechlorethamine is applied to skin.
    Please see "For the patient: Mechlorethamine for skin".

    Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
    kinds of cancer. It is a clear liquid that is usually injected into a vein.
    A blood sample will be taken before each treatment. The dose and timing of
    your chemotherapy may be changed based on your blood counts and/or other
    side effects.
    Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
    helps prevent kidney problems in some kinds of cancer.
    Other drugs may interact with mechlorethamine. Tell your doctor if you are
    taking any other drugs as your dose may need to be changed. Check with your
    doctor or pharmacist before you start taking any new drugs.
    The drinking of alcohol (in small amounts) will not affect the safety or
    usefulness of mechlorethamine.
    Mechlorethamine may cause sterility in men and menopause in women which may
    be permanent. If you plan to have children, discuss this with your doctor
    before being treated with mechlorethamine.
    Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
    It is best to use birth control while being treated with mechlorethamine. Tell
    your doctor right away if you or your partner becomes pregnant. Do not breast
    feed during treatment.
    Tell doctors or dentists that you are being treated with mechlorethamine before
    you receive any treatment from them.

    SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:

    Signs of an infection such as fever (over 100F or 38C); chills; cough; sore
    throat; pain or burning when you pass urine; redness, pain or swelling of any
    area of your body; sores forming anywhere on your body.
    Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
    red spots on skin.
    SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:

    Signs of kidney problems such as lower back or side pain, swelling of feet or
    lower legs, numbness or tingling in feet or hands.
    Signs of gout such as joint pain.
    CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:

    Uncontrolled nausea, vomiting or diarrhea.
    Easy bruising or bleeding.
    Redness, swelling, pain or sores where the needle was placed.
    Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
    Skin rash.

    Chlorethazine Organismes affectes

    Les humains et autres mammifères