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Celebrex Les marques, Celebrex Analogs

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  • Celebrex Formule chimique

    C17H14F3N3O2S

    Celebrex RX lien

    http://www.rxlist.com/cgi/generic/coxib.htm

    Celebrex FDA fiche

    Celebrex FDA

    Celebrex msds (fiche de securite des materiaux)

    Celebrex Synthese de reference

    Paradkar et al. Drug Dev Ind Pharm. 2003 29 (7) :739-44

    Celebrex Poids moleculaire

    381.373 g/mol

    Celebrex Point de fusion

    157-158oC

    Celebrex H2O Solubilite

    Celebrex Etat

    Solid

    Celebrex LogP

    4.157

    Celebrex Formes pharmaceutiques

    Gélules pour administration orale (100 mg, 200 mg ou 400 mg)

    Celebrex Indication

    Pour le soulagement et la gestion de l'ostéoarthrite (OA), la polyarthrite rhumatoïde (PR), la spondylarthrite ankylosante, de la douleur aiguë, la dysménorrhée primaire et complément par voie orale aux soins habituels pour les patients atteints de polypose adénomateuse familiale

    Celebrex Pharmacologie

    Le célécoxib, un cyclo-oxygénase-2 sélectifs (COX-2) inhibiteur, est classé comme un anti-inflammatoire non stéroïdien (AINS). Le célécoxib est utilisé pour traiter l'arthrite rhumatoïde, l'arthrose, et familial polypose adénomateuse (FAP). En raison de son absence d'effets de plaquettes, le célécoxib n'est pas un substitut à l'aspirine en prévention cardiovasculaire. On ne sait pas s'il ya des effets du célécoxib sur les plaquettes qui peuvent contribuer à l'augmentation du risque de thrombose cardiovasculaires graves événements indésirables associés à l'utilisation du célécoxib. L'inhibition de la synthèse de PGE2 peut conduire à la rétention de sodium et d'eau grâce à une réabsorption accrue dans la médullaire rénale épaisse boucle ascendante de Henle et peut-être d'autres segments du néphron distal. Dans les conduits de collecte, la PGE2 semble inhiber la réabsorption de l'eau en neutralisant l'action de l'hormone antidiurétique.

    Celebrex Absorption

    Eh bien absorbé dans le tractus gastro-intestinal. Lorsqu'il est pris avec un repas riche en graisses, les taux plasmatiques de pointe sont retardés pendant environ 1 à 2 heures avec une augmentation de l'absorption totale (ASC) de 10% à 20%.

    Celebrex Toxicite

    Les symptômes de surdose comprennent des difficultés respiratoires, un coma, somnolence, des saignements gastro-intestinaux, d'hypertension artérielle, d'insuffisance rénale, les nausées, la morosité, maux d'estomac et des vomissements.

    Celebrex Information pour les patients

    Medication Guide for
    Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

    What is the most important information I should know about medicines called Non-Steroidal AntiInflammatory Drugs (NSAIDs)?

    NSAID medicines may increase the chance of a heart attack or stroke that can lead to death. This chance increases: · with longer use of NSAID medicines · in people who have heart disease

    NSAID medicines should never be used right before or after a heart surgery called a ìcoronary artery bypass graft (CABG)."

    NSAID medicines can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding:
    · can happen without warning symptoms · may cause death

    The chance of a person getting an ulcer or bleeding increases with:
    · taking medicines called ìcorticosteroidsî and ìanticoagulantsî · longer use · smoking · drinking alcohol · older age · having poor health

    NSAID medicines should only be used:
    · exactly as prescribed
    · at the lowest dose possible for your treatment · for the shortest time needed

    What are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?
    NSAID medicines are use to treat pain and redness, swelling, and heat (inflammation) from medical conditions such as: · different types of arthritis · menstrual cramps and other types of short-term pain

    Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)? Do not take an NSAID medicine:
    · if you had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine · for pain right before or after heart bypass surgery Tell your healthcare provider:
    · about all of your medical conditions.
    · about all of the medicines you take. NSAIDs and some other medicines can interact with each other and cause serious side effects. Keep a list of your medicines to show to your healthcare provider and pharmacist. · if you are pregnant. NSAID medicines should not be used by pregnant women late in their pregnancy.
    · if you are breastfeeding. Talk to your doctor.

    What are the possible side effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?

    Serious side effects include: Other side effects include:
    · heart attack · stomach pain
    · stroke · constipation
    · high blood pressure · diarrhea
    · heart failure from body swelling (fluid retention) · gas
    · kidney problems including kidney failure · heartburn
    · bleeding and ulcers in the stomach and intestine · nausea
    · low red blood cells (anemia) · vomiting
    · life-threatening skin reactions · dizziness
    · life-threatening allergic reactions
    · liver problems including liver failure
    · asthma attacks in people who have asthma

    Get emergency help right away if you have any of the following symptoms:

    · shortnes s of breath or trouble breathing body
    · chest pain
    · slurred speech
    · weakness in one part or side of your
    · swelling of the face or throat

    Stop your NSAID medicine and call your healthcare provider right away if you have any of the following symptoms:

    · nausea
    · vomit blood
    · more tired or weaker than usual
    · there is blood in your bowel
    · itching movement or it is black and
    · your skin or eyes look yellow sticky like tar
    · stomach pain
    · skin rash or blisters with fever
    · flu-like symptoms
    · unusual weight gain
    · swelling of the arms and legs, hands and feet

    These are not all the side effects with NSAID medicines. Talk to your healthcare provider or pharmacist for more information about NSAID medicines.

    Other information about Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

    · Aspirin is an NSAID medicine but it does not increase the chance of a heart attack. Aspirin can cause bleeding in the brain, stomach, and intestines. Aspirin can also cause ulcers in the stomach and intestines.

    · Some of these NSAID medicines are sold in lower doses without a prescription (over ñthe ñcounter). Talk to your healthcare provider before using over ñthe ñcounter NSAIDs for more than 10 days.

    NSAID medicines that need a prescription

    Generic Name Tradename
    Celecoxib Celebrex
    Diclofenac Cataflam, Voltaren, Arthrotec (combined with misoprostol)
    Diflunisal Dolobid
    Etodolac Lodine, Lodine XL
    Fenoprofen Nalfon, Nalfon 200
    Flurbiprofen Ansaid
    Ibuprofen Motrin, Tab-Profen, Vicoprofen (combined with hydrocodone), Combunox (combined with oxycodone)
    Indomethacin Indocin, Indocin SR, Indo-Lemmon, Indomethagan
    Ketoprofen Oruvail
    Ketorolac Toradol
    Mefenamic Acid Ponstel
    Meloxicam Mobic
    Nabumetone Relafen
    Naproxen Naprosyn, Anaprox, Anaprox DS, EC-Naproxyn, Naprelan, Naprapac (copackaged with lansoprazole)
    Oxaprozin Daypro
    Piroxicam Feldene
    Sulindac Clinoril
    Tolmetin Tolectin, Tolectin DS, Tolectin 600

    This Medication Guide has been approved by the U.S. Food and Drug Administration.

     

     

    Celebrex Organismes affectes

    Les humains et autres mammifères