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Celebrex Nombres de marca, Celebrex Analogos

Celebrex Marca los nombres de mezcla

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  • Celebrex Formula quimica

    C17H14F3N3O2S

    Celebrex RX enlace

    http://www.rxlist.com/cgi/generic/coxib.htm

    Celebrex FDA hoja

    Celebrex FDA

    Celebrex MSDS (hoja de seguridad de materiales)

    Celebrex Sintesis de referencia

    Paradkar et al., Drug Dev. Ind. Pharm. 2003 29 (7) :739-44

    Celebrex Peso molecular

    381.373 g/mol

    Celebrex Punto de fusion

    157-158oC

    Celebrex H2O Solubilidad

    De agua muy baja solubilidad (3.3 mg / L)

    Celebrex Estado

    Solid

    Celebrex LogP

    4.157

    Celebrex Formas de dosificacion

    Cápsulas de administración oral (100 mg, 200 mg o 400 mg)

    Celebrex Indicacion

    Para el alivio y la gestión de la osteoartritis (OA), artritis reumatoide (AR), espondilitis anquilosante, dolor agudo, la dismenorrea primaria y adyuvante oral a la atención habitual para los pacientes con poliposis adenomatosa familiar

    Celebrex Farmacologia

    Celecoxib, un ciclooxigenasa-2 (COX-2) inhibidores, se clasifica como antiinflamatorios no esteroideos (AINE). Celecoxib se usa para tratar la artritis reumatoide, la osteoartritis y familiares poliposis adenomatosa familiar (PAF). Debido a su falta de efectos plaquetarios, celecoxib no es un sustituto de la aspirina para la profilaxis cardiovascular. No se sabe si hay algún efecto de celecoxib sobre las plaquetas, que puede contribuir al aumento del riesgo de eventos trombóticos cardiovasculares serios efectos adversos asociados con el uso de celecoxib. La inhibición de la síntesis de PGE2 puede conducir a la retención de sodio y agua a través de la reabsorción de aumento en la medular renal gruesa asa ascendente de Henle y tal vez otros segmentos de la nefrona distal. En los túbulos colectores, PGE2 parece inhibir la reabsorción de agua contrarrestando la acción de la hormona antidiurética.

    Celebrex Absorcion

    Se absorbe bien en el tracto gastrointestinal. Cuando se toma con una comida rica en grasas, los niveles plasmáticos máximos se retrasó alrededor de 1 a 2 horas con un aumento en la absorción total (AUC) de 10% a 20%.

    Celebrex Toxicidad

    Los síntomas de sobredosis incluyen dificultad para respirar, coma, somnolencia, sangrado gastrointestinal, hipertensión arterial, insuficiencia renal, náuseas, pesadez, dolor de estómago y vómitos.

    Celebrex Informacion de Pacientes

    Medication Guide for
    Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

    What is the most important information I should know about medicines called Non-Steroidal AntiInflammatory Drugs (NSAIDs)?

    NSAID medicines may increase the chance of a heart attack or stroke that can lead to death. This chance increases: · with longer use of NSAID medicines · in people who have heart disease

    NSAID medicines should never be used right before or after a heart surgery called a ìcoronary artery bypass graft (CABG)."

    NSAID medicines can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding:
    · can happen without warning symptoms · may cause death

    The chance of a person getting an ulcer or bleeding increases with:
    · taking medicines called ìcorticosteroidsî and ìanticoagulantsî · longer use · smoking · drinking alcohol · older age · having poor health

    NSAID medicines should only be used:
    · exactly as prescribed
    · at the lowest dose possible for your treatment · for the shortest time needed

    What are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?
    NSAID medicines are use to treat pain and redness, swelling, and heat (inflammation) from medical conditions such as: · different types of arthritis · menstrual cramps and other types of short-term pain

    Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)? Do not take an NSAID medicine:
    · if you had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine · for pain right before or after heart bypass surgery Tell your healthcare provider:
    · about all of your medical conditions.
    · about all of the medicines you take. NSAIDs and some other medicines can interact with each other and cause serious side effects. Keep a list of your medicines to show to your healthcare provider and pharmacist. · if you are pregnant. NSAID medicines should not be used by pregnant women late in their pregnancy.
    · if you are breastfeeding. Talk to your doctor.

    What are the possible side effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?

    Serious side effects include: Other side effects include:
    · heart attack · stomach pain
    · stroke · constipation
    · high blood pressure · diarrhea
    · heart failure from body swelling (fluid retention) · gas
    · kidney problems including kidney failure · heartburn
    · bleeding and ulcers in the stomach and intestine · nausea
    · low red blood cells (anemia) · vomiting
    · life-threatening skin reactions · dizziness
    · life-threatening allergic reactions
    · liver problems including liver failure
    · asthma attacks in people who have asthma

    Get emergency help right away if you have any of the following symptoms:

    · shortnes s of breath or trouble breathing body
    · chest pain
    · slurred speech
    · weakness in one part or side of your
    · swelling of the face or throat

    Stop your NSAID medicine and call your healthcare provider right away if you have any of the following symptoms:

    · nausea
    · vomit blood
    · more tired or weaker than usual
    · there is blood in your bowel
    · itching movement or it is black and
    · your skin or eyes look yellow sticky like tar
    · stomach pain
    · skin rash or blisters with fever
    · flu-like symptoms
    · unusual weight gain
    · swelling of the arms and legs, hands and feet

    These are not all the side effects with NSAID medicines. Talk to your healthcare provider or pharmacist for more information about NSAID medicines.

    Other information about Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

    · Aspirin is an NSAID medicine but it does not increase the chance of a heart attack. Aspirin can cause bleeding in the brain, stomach, and intestines. Aspirin can also cause ulcers in the stomach and intestines.

    · Some of these NSAID medicines are sold in lower doses without a prescription (over ñthe ñcounter). Talk to your healthcare provider before using over ñthe ñcounter NSAIDs for more than 10 days.

    NSAID medicines that need a prescription

    Generic Name Tradename
    Celecoxib Celebrex
    Diclofenac Cataflam, Voltaren, Arthrotec (combined with misoprostol)
    Diflunisal Dolobid
    Etodolac Lodine, Lodine XL
    Fenoprofen Nalfon, Nalfon 200
    Flurbiprofen Ansaid
    Ibuprofen Motrin, Tab-Profen, Vicoprofen (combined with hydrocodone), Combunox (combined with oxycodone)
    Indomethacin Indocin, Indocin SR, Indo-Lemmon, Indomethagan
    Ketoprofen Oruvail
    Ketorolac Toradol
    Mefenamic Acid Ponstel
    Meloxicam Mobic
    Nabumetone Relafen
    Naproxen Naprosyn, Anaprox, Anaprox DS, EC-Naproxyn, Naprelan, Naprapac (copackaged with lansoprazole)
    Oxaprozin Daypro
    Piroxicam Feldene
    Sulindac Clinoril
    Tolmetin Tolectin, Tolectin DS, Tolectin 600

    This Medication Guide has been approved by the U.S. Food and Drug Administration.

     

     

    Celebrex Organismos afectados

    Humanos y otros mamíferos