Naltrexone

• Anti-craving Agents
• Depressants
• Alcohol Antagonists
• Opiate Antagonists
• ATC:N07BB04

• Celupan
• N-Cyclopropylmethylnoroxymorphone
• Naltrexona [Inn-Spanish]
• Naltrexone Hcl
• Naltrexone [Usan:Ban:Inn]
• Naltrexonum [Inn-Latin]
• ReVia
• Vivitrex

No information avaliable

C₂₀H₂₃NO₄

http://www.rxlist.com/cgi/generic2/naltrexone.htm

Naltrexone FDA

Naltrexone MSDS

No hay información disponible

341.401 g/mol

169-170 ^oC (274-276 ^oC for hydrochloride salt)

100 mg / ml (como clorhidrato)

Solid

1.692 (1.92 by expt)

Tablet (anotó, recubiertos con película, 50 mg)

Para su uso en el tratamiento de la dependencia del alcohol y por el bloqueo de los efectos de los opiáceos administrados exógenamente.

La naltrexona, un antagonista opiáceo puro, es un congénere sintético de la oximorfona sin propiedades agonistas opioides. La naltrexona está indicada en el tratamiento de la dependencia del alcohol y por el bloqueo de la efectos de los opiáceos administrados exógenamente. Es notable atenúa o bloquea por completo, de forma reversible, los efectos subjetivos de los opiáceos administrados por vía intravenosa. Cuando se co-administra con morfina, en de manera crónica, la naltrexona bloquea la dependencia física a los opioides morfina, heroína y otras. En los sujetos con dependencia física a los opioides, la naltrexona se precipita la retirada sintomatología.

Aunque se absorbe bien por vía oral, la naltrexona está sujeto a un importante metabolismo de primer paso con las estimaciones de la biodisponibilidad oral de 5 a 40%.

En el cerdo ratones, ratas y cobayas, la DL50 oral fueron 1,100-1,550 mg / kg, 1.450 mg / kg y 1.490 mg / kg, respectivamente. Las altas dosis de naltrexona (generalmente ≥ 1.000 mg / kg) produce salivación, depresión y / o reducción de la actividad, temblores, y convulsiones.

It is recommended that the prescribing physician relate the following information to patients being treated with REVIA:

You have been prescribed REVIA as part of the comprehensive treatment for your alcoholism or drug dependence. You should carry identification to alert medical personnel to the fact that you are taking REVIA. A REVIA medication card may be obtained from your physician and can be used for this purpose. Carrying the identification card should help to ensure that you can obtain adequate treatment in an emergency. If you require medical treatment, be sure to tell the treating physician that you are receiving REVIA therapy.

You should take REVIA as directed by your physician. If you attempt to self-administer heroin or any other opiate drug, in small doses while on REVIA, you will not perceive any effect. Most important, however, if you attempt to self-administer large doses of heroin or any other opioid while on REVIA, you may die or sustain serious injury, including coma.

REVIA is well-tolerated in the recommended doses, but may cause liver injury when taken in excess or in people who develop liver disease from other causes. If you develop abdominal pain lasting more than a few days, white bowel movements, dark urine, or yellowing of your eyes, you should stop taking REVIA immediately and see your doctor as soon as possible.

Humanos y otros mamíferos