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N-Cyclopropylmethylnoroxymorphone Nombres de marca, N-Cyclopropylmethylnoroxymorphone Analogos

N-Cyclopropylmethylnoroxymorphone Marca los nombres de mezcla

  • No information avaliable

    • N-Cyclopropylmethylnoroxymorphone Formula quimica

    C20H23NO4

    N-Cyclopropylmethylnoroxymorphone RX enlace

    http://www.rxlist.com/cgi/generic2/naltrexone.htm

    N-Cyclopropylmethylnoroxymorphone FDA hoja

    N-Cyclopropylmethylnoroxymorphone FDA

    N-Cyclopropylmethylnoroxymorphone MSDS (hoja de seguridad de materiales)

    N-Cyclopropylmethylnoroxymorphone MSDS

    N-Cyclopropylmethylnoroxymorphone Sintesis de referencia

    No hay información disponible

    N-Cyclopropylmethylnoroxymorphone Peso molecular

    341.401 g/mol

    N-Cyclopropylmethylnoroxymorphone Punto de fusion

    169-170 oC (274-276 oC for hydrochloride salt)

    N-Cyclopropylmethylnoroxymorphone H2O Solubilidad

    100 mg / ml (como clorhidrato)

    N-Cyclopropylmethylnoroxymorphone Estado

    Solid

    N-Cyclopropylmethylnoroxymorphone LogP

    1.692 (1.92 by expt)

    N-Cyclopropylmethylnoroxymorphone Formas de dosificacion

    Tablet (anotó, recubiertos con película, 50 mg)

    N-Cyclopropylmethylnoroxymorphone Indicacion

    Para su uso en el tratamiento de la dependencia del alcohol y por el bloqueo de los efectos de los opiáceos administrados exógenamente.

    N-Cyclopropylmethylnoroxymorphone Farmacologia

    La naltrexona, un antagonista opiáceo puro, es un congénere sintético de la oximorfona sin propiedades agonistas opioides. La naltrexona está indicada en el tratamiento de la dependencia del alcohol y por el bloqueo de la efectos de los opiáceos administrados exógenamente. Es notable atenúa o bloquea por completo, de forma reversible, los efectos subjetivos de los opiáceos administrados por vía intravenosa. Cuando se co-administra con morfina, en de manera crónica, la naltrexona bloquea la dependencia física a los opioides morfina, heroína y otras. En los sujetos con dependencia física a los opioides, la naltrexona se precipita la retirada sintomatología.

    N-Cyclopropylmethylnoroxymorphone Absorcion

    Aunque se absorbe bien por vía oral, la naltrexona está sujeto a un importante metabolismo de primer paso con las estimaciones de la biodisponibilidad oral de 5 a 40%.

    N-Cyclopropylmethylnoroxymorphone Toxicidad

    En el cerdo ratones, ratas y cobayas, la DL50 oral fueron 1,100-1,550 mg / kg, 1.450 mg / kg y 1.490 mg / kg, respectivamente. Las altas dosis de naltrexona (generalmente ≥ 1.000 mg / kg) produce salivación, depresión y / o reducción de la actividad, temblores, y convulsiones.

    N-Cyclopropylmethylnoroxymorphone Informacion de Pacientes

    It is recommended that the prescribing physician relate the following information to patients being treated with REVIA:

    You have been prescribed REVIA as part of the comprehensive treatment for your alcoholism or drug dependence. You should carry identification to alert medical personnel to the fact that you are taking REVIA. A REVIA medication card may be obtained from your physician and can be used for this purpose. Carrying the identification card should help to ensure that you can obtain adequate treatment in an emergency. If you require medical treatment, be sure to tell the treating physician that you are receiving REVIA therapy.

    You should take REVIA as directed by your physician. If you attempt to self-administer heroin or any other opiate drug, in small doses while on REVIA, you will not perceive any effect. Most important, however, if you attempt to self-administer large doses of heroin or any other opioid while on REVIA, you may die or sustain serious injury, including coma.

    REVIA is well-tolerated in the recommended doses, but may cause liver injury when taken in excess or in people who develop liver disease from other causes. If you develop abdominal pain lasting more than a few days, white bowel movements, dark urine, or yellowing of your eyes, you should stop taking REVIA immediately and see your doctor as soon as possible.

    N-Cyclopropylmethylnoroxymorphone Organismos afectados

    Humanos y otros mamíferos