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Frova Nombres de marca, Frova Analogos

Frova Marca los nombres de mezcla

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  • Frova Formula quimica


    Frova RX enlace

    Frova FDA hoja

    Frova FDA

    Frova MSDS (hoja de seguridad de materiales)

    Frova Sintesis de referencia

    No hay información disponible

    Frova Peso molecular

    243.304 g/mol

    Frova Punto de fusion

    No information avaliable

    Frova H2O Solubilidad


    Frova Estado


    Frova LogP

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    Frova Formas de dosificacion


    Frova Indicacion

    Para el tratamiento agudo de ataques de migraña con o sin aura en adultos.

    Frova Farmacologia

    Frovatriptán es una segunda generación de triptanos 5-HT agonista del receptor que se une con alta afinidad por la 5-HT 1B y los receptores 5-HT1D. Frovatriptán no tiene efectos significativos sobre la actividad de GABA mediada por canal y no tiene afinidad significativa por los sitios de unión de las benzodiazepinas. Frovatriptán se cree que actúa sobre las arterias extracerebrales intracraneales y para inhibir la excesiva dilatación de estos vasos en la migraña. La investigación ha demostrado que la migraña puede ser causada por la inflamación de los vasos sanguíneos en el cerebro. Frovatriptán alivia el dolor asociado con la migraña por el estrechamiento de estos vasos sanguíneos. Frovatriptán ha una de las mayores afinidades por la 5-HT 1B de los agonistas de la segunda generación de los triptanos.

    Frova Absorcion

    Frovatriptán se absorbe rápidamente en el duodeno, pero tiene baja biodisponibilidad oral.

    Frova Toxicidad

    No hay experiencia directa de cualquier paciente que toma una sobredosis de frovatriptán. La dosis única máxima de frovatriptán administrado a pacientes hombres y mujeres con migraña fue de 40 mg (16 veces la clínica dosis) y la dosis única máxima atención a varones sanos fue de 100 mg (40 veces la dosis clínica), sin efectos adversos significativos.

    Frova Informacion de Pacientes

    FROVATM (frovatriptan succinate) Tablets

    Read this information before you start taking FROVA (FRO-va). Also, read the information each time you renew your prescription, in case anything has changed. This leaflet does not contain all of the information about FROVA. For further information or advice ask your doctor or pharmacist. You and your doctor should discuss FROVA before you start taking the medicine and at regular checkups.

    What is FROVA?

    FROVA is a prescription medicine used to treat migraine attacks in adults. It is in the class of drugs called selective serotonin receptor agonists. FROVA should only be taken for a migraine headache. Do not use FROVA to treat headaches that might be caused by other conditions. Tell your doctor about your symptoms. Your doctor will decide if you have migraine headaches and if FROVA is for you. There is more information about migraine at the end of this leaflet.

    Who should not take FROVA?

    Do not take FROVA if you:

    * have uncontrolled high blood pressure

    * have heart disease or a history of heart disease

    * have hemiplegic or basilar migraine (if you are not sure about this, ask your doctor)

    * have had a stroke

    * have circulation (blood flow) problems

    * have taken a similar drug (a serotonin receptor agonist) in the last 24 hours. These include sumatriptan (IMITREX® ), naratriptan (AMERGE® ) zolmitriptan (ZOMIG® ), rizatriptan (MAXALT® ), or almotriptan (AXERTTM)

    * have taken ergotamine type medicines in the last 24 hours. These include BELLERGAL®, CAFERGOT®, ERGOMAR®, WIGRAINE®, DHE 45®, or SANSERT®

    * have any allergic reaction to the tablet

    What should you tell your doctor before and during treatment with FROVA?

    To help your doctor decide if FROVA is right for you, tell your doctor if you:

    * are pregnant, or planning to become pregnant

    * are breast-feeding or plan to breast-feed
    * have any history of chest pain, shortness of breath, or palpitations
    * have any risk factors for heart disease, including

    - high blood pressure
    - diabetes
    - high cholesterol
    - overweight
    - smoking
    - a family history of heart disease
    - past menopause
    - male over 40 years old
    - are taking any other medicine, including prescription and nonprescription medicines, and herbal supplements

    * have any past or present medical problems
    * have previous allergies to any medicine Tell your doctor if you take
    * propranolol
    * selective serotonin reuptake inhibitors (SSRIs) such as Prozac® (fluoxetine), Luvox® (fluvoxamine), Paxil® (paroxetine), and Zoloft® (sertraline) These medicines may affect how FROVA works, or FROVA may affect how these medicines work.

    How should you take FROVA?

    * Take one FROVA tablet anytime after the start of your migraine headache.

    * If your headache comes back after your first dose, you may take a second tablet after two (2) hours. Do not take more than three (3) FROVA tablets in a 24-hour period.

    * If you take too much medicine, contact your doctor, hospital emergency department, or poison control center right away.

    What are the common side effects of FROVA?

    The most common side effects associated with use of FROVA are:
    * dizziness
    * fatigue (tiredness)
    * headache (other than a migraine headache)
    * paresthesia (feeling of tingling)
    * dry mouth
    * flushing (hot flashes)
    * feeling hot or cold
    * chest pain
    * dyspepsia (indigestion)
    * skeletal pain (pain in joints or bones)

    Tell your doctor about any symptoms that you develop while taking FROVA. If you feel dizziness or fatigue, take extra care or avoid driving and operating machinery.

    In very rare cases, patients taking this class of medicines experience serious heart problems, stroke, or increased blood pressure. If you develop pain, tightness, heaviness, or pressure in your chest, throat, neck, or jaw, contact your doctor right away. Also contact your doctor right away if you develop a rash or itching after taking FROVA. You may be allergic to this medicine.

    What is a migraine and how does it differ from other headaches?

    Migraine is an intense, throbbing headache that often affects one side of the head. It often includes nausea, vomiting, and sensitivity to light and sound. The pain and symptoms from a migraine headache may be worse than the pain and symptoms of a common headache. Migraine headaches usually last for hours or longer.

    Some people have problems with vision (an aura) before they get a migraine headache. These include flashing lights, wavy lines, and dark spots.

    Only your doctor can determine that your headache is a migraine headache, so it is important that you discuss all of your symptoms with your doctor.

    Manufactured under license from Vernalis Limited., FROVA is a trademark of Vernalis Development Limited.
    © 2002 Elan Pharmaceuticals, Inc.

    Frova Organismos afectados

    Humanos y otros mamíferos