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Analogos
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Calcimate Plus Calcium, Potassium, Magnesium and Vitamin D (Calcium (Calcium Citrate, Calcium Malate) + Magnesium (Magnesium Oxide) + Potassium (Potassium Chloride) + Vitamin D2 (Ergocalciferol)) Calcium and Magnesium Citrate with Vitamin D (Calcium (Calcium Citrate) + Magnesium (Magnesium Citrate) + Vitamin D (Ergocalciferol)) Calcium Magnesium 2:1 Tablets with Vitamin D (Calcium (Calcium Citrate) + Magnesium (Magnesium Oxide) + Vitamin D2 (Ergocalciferol)) Centrum 8409 (Beta-Carotene + Biotin + Chromium (Chromic Chloride) + Copper (Cupric Oxide) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Iodine (Potassium Iodide) + Iron (Ferronyl) + Manganese (Manganese Sulfate) + Molybdenum (Sodium Molybdate) + Nicotinamide + Vitamin a (Vitamin a Acetate) + Vitamin B1 (Thiamine Mononitrate) + Vitamin B12 (Cyanocobalamin) + Vitamin B2 (Riboflavin) + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C (Ascorbic Acid) + Vitamin D2 (Ergocalciferol) + Vitamin E (Vitamin E Acetate) + Vitamin K1 (Phytonadione) + Zinc (Zinc Oxide)) Insur-All Vitamin Supplement (Biotin + Choline Bitartrate + D-Pantothenic Acid + Inositol + Nicotinamide + Vitamin a (Vitamin a Acetate) + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B12 (Cyanocobalamin) + Vitamin B2 + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C + Vitamin D (Ergocalciferol) + Vitamin E (Dl-Alpha Tocopheryl Acetate)) Mega Halibut Liver Oil (Vitamin a (Halibut Liver Oil) + Vitamin D (Ergocalciferol)) Msb Essentials (Beta-Carotene + Biotin + Calcium (Calcium Citrate) + Choline Dihydrogen Citrate + Chromium (Chromic Chloride) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Inositol + Iodine (Potassium Iodide) + Iron (Ferrous Fumarate) + Magnesium (Magnesium Citrate) + Manganese (Manganese Hvp Chelate) + Methionine + Molybdenum (Sodium Molybdate) + Nicotinamide + Nicotinic Acid + Potassium (Potassium Citrate) + Selenium (Selenium Hvp Chelate) + Vitamin a (Vitamin a Acetate) + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B12 + Vitamin B2 (Riboflavin-5-Phosphate) + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C + Vitamin D (Ergocalciferol) + Vitamin E (D-Alpha Tocopherol) + Zinc (Zinc Chloride)) Pre-Natal (Beta-Carotene (Provitamin a) + Biotin + Calcium (Calcium Citrate, Calcium Carbonate) + Chromium (Chromium Hvp Chelate) + Copper (Copper Hvp Chelate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Iodine (Potassium Iodide) + Iron (Iron Citrate) + Magnesium (Magnesium Hvp Chelate) + Manganese (Manganese Hvp Chelate) + Molybdenum (Molybdenum Hvp Chelate) + Nicotinamide + Potassium (Potassium Citrate) + Selenium (Selenium Hvp Chelate) + Silicon (Silicon Dioxide) + Vitamin a (Vitamin a Palmitate) + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B12 (Cyanocobalamin) + Vitamin B2 (Riboflavin Hydrochloride, Riboflavin-5-Phosphate) + Vitamin B6 (Pyridoxine Hydrochloride, Pyridoxine 5' Phosphate) + Vitamin C (Calcium Ascorbate) + Vitamin D2 (Ergocalciferol) + Vitamin E (D-Alpha Tocopheryl Acid Succinate) + Zinc (Zinc Hvp Chelate)) Super Thera-M (Beta-Carotene (Provitamin a) + Biotin + Calcium (Calcium Phosphate (Dibasic)) + Chloride (Potassium Chloride) + Chromium (Chromic Chloride) + Copper (Cupric Sulfate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Iodine (Potassium Iodide, Kelp) + Iron (Ferrous Fumarate) + Magnesium (Magnesium Oxide) + Manganese (Manganese Sulfate) + Molybdenum (Sodium Molybdate) + Nicotinic Acid (Nicotinamide) + Phosphorus (Calcium Phosphate (Dibasic)) + Potassium (Potassium Chloride) + Selenium (Sodium Selenate) + Vitamin a (Vitamin a Palmitate) + Vitamin B1 (Thiamine Mononitrate) + Vitamin B12 (Cyanocobalamin) + Vitamin B2 (Riboflavin) + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C (Ascorbic Acid) + Vitamin D2 (Ergocalciferol) + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc (Zinc Sulfate)) Timed Release Multi Vitamin with Chelated Minerals (Beta-Carotene (Provitamin a) + Biotin + Calcium (Calcium Hvp Chelate, Calcium Phosphate (Tribasic)) + Choline Bitartrate + Chromium (Chromium Hvp Chelate) + Copper (Copper Gluconate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Dl-Methionine + Folic Acid + Inositol + Iodine (Potassium Iodide, Kelp) + Iron (Iron Hvp Chelate, Ferrous Fumarate) + Magnesium (Magnesium Oxide, Magnesium Hvp Chelate) + Manganese (Manganese Hvp Chelate) + Nicotinamide + Potassium (Potassium Chloride, Potassium Citrate) + Selenium (Selenium Hvp Chelate) + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B2 (Riboflavin) + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C (Ascorbic Acid) + Vitamin D (Ergocalciferol) + Vitamin E (D-Alpha Tocopheryl Acetate) + Zinc (Zinc Hvp Chelate))
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Formula quimica
C28H44O
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RX enlace
http://www.rxlist.com/cgi/generic2/calcitri.htm
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FDA hoja
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MSDS (hoja de seguridad de materiales)
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Sintesis de referencia
Sicinski RR et al., Anal Biochem.161 (1) :96-102
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Peso molecular
396.648 g/mol
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Punto de fusion
115.0-119.0 oC
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H2O Solubilidad
Insoluble
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Estado
Solid
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LogP
6.388
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Formas de dosificacion
Gotas, cápsulas, solución, tableta, inyección
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Indicacion
Para el TRATAMIENTO de la deficiencia de vitamina D o la insuficiencia, el raquitismo refractario (vitamina D raquitismo resistente), hipofosfatemia familiar y el hipoparatiroidismo y en la gestión de la hipocalcemia y la osteodistrofia renal en pacientes con diálisis insuficiencia renal crónica sometidos. También se utiliza en combinación con el calcio en la gestión y prevención de la osteoporosis inducida por corticosteroides o primaria. .
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Farmacologia
Utilizados en el tratamiento de la hypcalcemia y dependientes de diálisis renal. Ergoalcifediol (vitamina D2) es una grasa soluble precursor de las hormonas esteroides de la vitamina D, que contribuye al mantenimiento de los niveles normales de calcio y fósforo en el torrente sanguíneo.
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Absorcion
Absorbe fácilmente en el intestino delgado (proximal o distal), requiere la presencia de sales biliares.
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Toxicidad
LD50 = 23,7 mg / kg (por vía oral en ratones), DL50 = 10 mg / kg (por vía oral en ratas), náuseas, vómitos y diarrea, pérdida de peso, irritabilidad, debilidad, fatiga, cansancio y dolor de cabeza.
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Informacion de Pacientes
Patient information for vitamin D analogues (Vitamin D2, Vitamin D3, Calcitriol, and Calcidiol):
The patient and his or her parents or s.o.s. should be informed about compliance with dosage instructions, adherence to instructions about diet and calcium supplementation and avoidance of the use of unapproved nonprescription drugs. Patients should also be carefully informed about the symptoms of hypercalcemia.
The effectiveness of vitamin D therapy is predicated on the assumption that each patient is receiving an adequate daily intake of calcium. Patients are advised to have a dietary intake of calcium at a minimum of 600 mg daily. The U.S. RDA for calcium in adults is 800 mg to 1200 mg.
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Organismos afectados
Humanos y otros mamíferos