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  • Alfadil Formula quimica


    Alfadil RX enlace

    Alfadil FDA hoja

    Alfadil FDA

    Alfadil MSDS (hoja de seguridad de materiales)

    Alfadil Sintesis de referencia

    SF Campbell, EE.UU. Pat. 4,188,390 (1980)

    Alfadil Peso molecular

    451.475 g/mol

    Alfadil Punto de fusion


    Alfadil H2O Solubilidad

    24 mg / L

    Alfadil Estado


    Alfadil LogP


    Alfadil Formas de dosificacion

    Tablet (oral)

    Alfadil Indicacion

    Para el tratamiento y manejo de la hipertensión y los síntomas urinarios obstrucción de la HPB.

    Alfadil Farmacologia

    La doxazosina es un agente alfa-bloqueante utilizado para tratar la hipertensión y la hiperplasia benigna de próstata. Por lo tanto, doxazosina es un inhibidor selectivo del subtipo alfa-1 de los receptores alfa adrenérgicos. En la próstata humana, doxazosina antagoniza fenilefrina (alfa1 agonistas) las contracciones inducidas, in vitro, y se une con gran afinidad a los receptores adrenérgicos de la alpha1c, que se cree que es la predominante tipo funcional en la próstata. Los estudios realizados en sujetos humanos normales han demostrado que la doxazosina competitivos antagoniza los efectos presores de la fenilefrina (un agonista alfa-1) y el efecto presor sistólica de la norepinefrina. El efecto antihipertensivo de doxazosina resultados de una disminución de la resistencia vascular sistémica y la doxazosina compuesto original es el principal responsable de la actividad antihipertensiva. .

    Alfadil Absorcion


    Alfadil Toxicidad

    Los síntomas de sobredosis incluyen hipotensión. DL50 oral es superior a 1000 mg / kg en ratones y ratas.

    Alfadil Informacion de Pacientes

    Read This:
    Before you start taking doxazosin mesylate.
    Each time you get a new prescription.
    You and your doctor should discuss this treatment and your BPH symptoms before you start taking doxazosin mesylate and at your regular checkups. This leaflet does NOT take the place of discussions with your doctor.

    Doxazosin mesylate is used to treat both benign prostatic hyperplasia (BPH) and high blood pressure (hypertension). This leaflet describes doxazosin mesylate as treatment for BPH (although you may be taking doxazosin mesylate for both your BPH and high blood pressure).

    Doxazosin mesylate works on a specific type of muscle found in the prostate, causing it to relax. This in turn decreases the pressure within the prostate, thus improving the wflow of urine and your symptoms.

    Doxazosin mesylate helps relieve the symptoms of BPH (weak stream, start-and-stop stream, a feeling that your bladder is not completely empty, delay in beginning of urination, need to urinate often during the day and especially at night, and feeling that you must urinate immediately). It does not change the size of the prostate. The prostate may continue to grow; however, a larger prostate is not necessarily related to more symptoms or to worse symptoms. Doxazosin mesylate can decrease your symptoms and improve urinary flow, without decreasing the size of the prostate.
    If doxazosin mesylate is helping you, you should notice an effect within 1 to 2 weeks after you start your medication. Doxazosin mesylate has been studied in over 900 patients for up to 2 years and the drug has been shown to continue to work during long-term treatment. Even though you take doxazosin mesylate and it may help you, doxazosin mesylate may not prevent the need for surgery in the future.
    Doxazosin mesylate does not affect PSA levels. PSA is the abbreviation for Prostate Specific Antigen. Your doctor may have done a blood test called PSA. You may want to ask your doctor more about this if you have had a PSA test done.
    Other Important Facts

    You should see an improvement of your symptoms within 1 to 2 weeks. In addition to your other regular checkups you will need to continue seeing your doctor regularly to check your progress regarding your BPH and to monitor your blood pressure.
    Doxazosin mesylate is not a treatment for prostate cancer. Your doctor has prescribed doxazosin mesylate for your BPH and not for prostate cancer; however, a man can have BPH and prostate cancer at the same time. Doctors usually recommend that men be checked for prostate cancer once a year when they turn 50 (or 40 if a family member has had prostate cancer). A higher incidence of prostate cancer has been noted in men of African-American descent. These checks should continue even if you are taking doxazosin mesylate.
    How To Take Doxazosin Mesylate and What You Should Know While Taking Doxazosin Mesylate for BPH

    Doxazosin mesylate can cause a sudden drop in blood pressure after the VERY FIRST DOSE. You may feel dizzy, faint or light-headed, especially after you stand up from a lying or sitting position. This is more likely to occur after you've taken the first few doses or if you increase your dose, but can occur at any time while you are taking the drug. It can also occur if you stop taking the drug and then restart treatment. If you feel very dizzy, faint or light-headed you should contact your doctor. Your doctor will discuss with you how often you need to visit and how often your blood pressure should be checked.

    Your blood pressure should be checked when you start taking doxazosin mesylate even if you do not have high blood pressure (hypertension). Your doctor will discuss with you the details of how blood pressure is measured.

    Alfadil Organismos afectados

    Humanos y otros mamíferos