Valstar Preservative Free
Valstar Preservative Free Brand names, Valstar Preservative Free Analogs
Valstar Preservative Free Brand Names Mixture
- No information avaliable
Valstar Preservative Free Chemical_Formula
C34H36F3NO13
Valstar Preservative Free RX_link
http://www.rxlist.com/cgi/generic2/rubicin.htm
Valstar Preservative Free fda sheet
Valstar Preservative Free msds (material safety sheet)
Valstar Preservative Free Synthesis Reference
No information avaliable
Valstar Preservative Free Molecular Weight
723.644 g/mol
Valstar Preservative Free Melting Point
116-117oC
Valstar Preservative Free H2O Solubility
insoluble
Valstar Preservative Free State
Solid
Valstar Preservative Free LogP
3.332
Valstar Preservative Free Dosage Forms
Liquid
Valstar Preservative Free Indication
Bladder cancer
Valstar Preservative Free Pharmacology
When 800 mg Valstar was administered intravesically to patients with carcinoma in situ, Valstar penetrated into the bladder wall. The mean total anthracycline concentration measured in bladder tissue exceeded the levels causing 90% cytoxicity to human bladder cells cultured in vitro. During the two-hour dose-retention period, the metabolism of Valstar to its major metabolites N-trifluoroacetyladriamycin and N-trifluoroacetyladriamycinol was neglible. After retention, the drug was almost completely excreted by voiding the instillate. Mean percent recovery of Valstar, N-trifluoroacetyladriamycin, and total anthracyclines in 14 urine samples from six patients was 98.6%, 0.4%, and 99.0% of the total administered drug, respectively. During the two-hour dose-retention period, only nanogram quantities of Valstar were absorbed into the plasma.
Valstar Preservative Free Absorption
No information avaliable
Valstar Preservative Free side effects and Toxicity
No information avaliable
Valstar Preservative Free Patient Information
Valstar Preservative Free Organisms Affected
Humans and other mammals
