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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C14H16N2O2
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
244.289 g/mol
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Melting Point
67 oC
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H2O Solubility
63.2 mg/L
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State
Solid
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LogP
2.695
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Dosage Forms
Solution for injection (2 mg/mL)
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Indication
Used in the induction of general anesthesia.
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Pharmacology
Etomidate is a non-barbiturate hypnotic that acts at the level of the reticular-activating system to produce anesthesia. Etomidate is an imidazole compound that appears to depress CNS function via GABA. Duration of action is intermediate between thiopental and methohexital, and recovery from a single dose is rapid with little residual depression. Like the barbiturates and propofol, etomidate is does not induce analgesia. Etomidate induces unconsciousness within one circulation time. Recovery is rapid as a result of extensive redistribution and rapid metabolism.
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Absorption
No information avaliable
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side effects and Toxicity
Undesirable side effects of etomidate that may limit its use include pain on injection, myoclonus and adrenocortical suppression lasting 4-6 hours following an induction dose.
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals