Urokinase
Urokinase Brand names, Urokinase Analogs
Urokinase Brand Names Mixture
- No information avaliable
Urokinase Chemical_Formula
C1376H2145N383O406S18
Urokinase RX_link
http://www.rxlist.com/cgi/pharmclips2.cgi?keyword=%20Abbokinase%AE
Urokinase fda sheet
Urokinase msds (material safety sheet)
Urokinase Synthesis Reference
PMID 2987867
Urokinase Molecular Weight
31126.5
Urokinase Melting Point
76 oC at pH 4.5 (Nowak, U.K. et al., Biochemistry 33:2951-2960 (1994).
Urokinase H2O Solubility
No information avaliable
Urokinase State
Liquid
Urokinase LogP
-0.466
Urokinase Dosage Forms
Powder for solution; Solution (IV infusion)
Urokinase Indication
For the treatment of pulminary embolism, coronary artery thrombosis and IV catheter clearance
Urokinase Pharmacology
Urokinase is used for the treatment of pulmonary embolisms. The low molecular weight form of human urokinase consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Urokinase is an enzyme (protein) produced by the kidney, and found in the urine. There are two forms of urokinase which differ in molecular weight but have similar clinical effects. Urokinase is the low molecular weight form. Urokinase acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen and some other plasma proteins.
Urokinase Absorption
No information avaliable
Urokinase side effects and Toxicity
No information avaliable
Urokinase Patient Information
http://www.drugs.com/PDR/Abbokinase.html
Urokinase Organisms Affected
Humans and other mammals
