Urokinase

• Thrombolytic Agents
• ATC:B01AD04

• U-plasminogen activator
• Urokinase-type plasminogen activator precursor
• uPA
• Abbokinase (Abbott Laboratories)

• No information avaliable

C₁₃₇₆H₂₁₄₅N₃₈₃O₄₀₆S₁₈

http://www.rxlist.com/cgi/pharmclips2.cgi?keyword=%20Abbokinase%AE

http://redpoll.pharmacy.ualberta.ca/DrugBank/Urok001-FDA.pdf

PMID 2987867

31126.5

76 ^oC at pH 4.5 (Nowak, U.K. et al., Biochemistry 33:2951-2960 (1994).

No information avaliable

Liquid

-0.466

Powder for solution; Solution (IV infusion)

For the treatment of pulminary embolism, coronary artery thrombosis and IV catheter clearance

Urokinase is used for the treatment of pulmonary embolisms. The low molecular weight form of human urokinase consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Urokinase is an enzyme (protein) produced by the kidney, and found in the urine. There are two forms of urokinase which differ in molecular weight but have similar clinical effects. Urokinase is the low molecular weight form. Urokinase acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen and some other plasma proteins.

No information avaliable

No information avaliable

http://www.drugs.com/PDR/Abbokinase.html

Humans and other mammals